Browse

Synergistic interaction of high blood pressure and cerebral beta-amyloid on tau pathology

Cited 0 time in Web of Science Cited 0 time in Scopus
Authors

Kim, Taewon; Yi, Dahyun; Byun, Min Soo; Ahn, Hyejin; Jung, Joon Hyung; Kong, Nayeong; Kim, Min Jung; Jung, Gijung; Lee, Jun-Young; Lee, Yun-Sang; Kim, Yu Kyeong; Lee, Dong Young

Issue Date
2022-12-24
Publisher
BMC
Citation
Alzheimer's Research & Therapy, 14(1):193
Keywords
HypertensionBlood pressureAlzheimer’s diseasePositron emission tomographyBeta‑amyloidTau
Abstract
Background
Hypertension has been associated with Alzheimers disease (AD) dementia as well as vascular dementia. However, the underlying neuropathological changes that link hypertension to AD remain poorly understood. In our study, we examined the relationships of a history of hypertension and high current blood pressure (BP) with in vivo AD pathologies including β-amyloid (Aβ) and tau and also investigated whether a history of hypertension and current BP respectively affect the association between Aβ and tau deposition.


Methods
This cross-sectional study was conducted as part of the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimers Disease, a prospective cohort study. Cognitively normal older adults who underwent both Aβ and tau positron emission tomography (PET) (i.e., [11C]-Pittsburgh compound B and [18F] AV-1451 PET) were selected. History of hypertension and current BP were evaluated and cerebral Aβ and tau deposition measured by PET were used as main outcomes. Generalized linear regression models were used to estimate associations.


Results
A total of 68 cognitively normal older adults (mean [SD] age, 71.5 [7.4] years; 40 women [59%]) were included in the study. Neither a history of hypertension nor the current BP exhibited a direct association with Aβ or tau deposition. However, the synergistic interaction effects of high current systolic (β, 0.359; SE, 0.141; p = 0.014) and diastolic (β, 0.696; SE, 0.158; p < 0.001) BP state with Aβ deposition on tau deposition were significant, whereas there was no such effect for a history of hypertension (β, 0.186; SE, 0.152; p = 0.224).


Conclusions
The findings suggest that high current BP, but not a history of hypertension, synergistically modulate the relationship between cerebral Aβ and tau deposition in late-life. In terms of AD prevention, the results support the importance of strict BP control in cognitively normal older adults with hypertension.
ISSN
1758-9193
Language
English
URI
https://doi.org/10.1186/s13195-022-01149-7

https://hdl.handle.net/10371/187379
DOI
https://doi.org/10.1186/s13195-022-01149-7
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse