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Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction
Cited 1 time in
Web of Science
Cited 2 time in Scopus
- Authors
- Issue Date
- 2022-12
- Publisher
- Pergamon Press Ltd.
- Citation
- Progress in Neurobiology, Vol.219, p. 102369
- Abstract
- Sensing smells of foods, prey, or predators determines animal survival. Olfactory sensory neurons in the olfactory epithelium (OE) detect odorants, where cAMP and Ca2+ play a significant role in transducing odorant inputs to electrical activity. Here we show Anoctamin 9, a cation channel activated by cAMP/PKA pathway, is expressed in the OE and amplifies olfactory signals. Ano9-deficient mice had reduced olfactory behavioral sensitivity, electro-olfactogram signals, and neural activity in the olfactory bulb. In line with the difference in olfaction between birds and other vertebrates, chick ANO9 failed to respond to odorants, whereas chick CNGA2, a major trans-duction channel, showed greater responses to cAMP. Thus, we concluded that the signal amplification by ANO9 is important for mammalian olfactory transduction.
- ISSN
- 0301-0082
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