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Serum creatinine to cystatin C ratio and clinical outcomes in adults with non-dialysis chronic kidney disease
DC Field | Value | Language |
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dc.contributor.author | Hyun, Young Youl | - |
dc.contributor.author | Lee, Kyu-Beck | - |
dc.contributor.author | Kim, Hyoungnae | - |
dc.contributor.author | Kim, Yaeni | - |
dc.contributor.author | Chung, Wookyung | - |
dc.contributor.author | Park, Hayne Cho | - |
dc.contributor.author | Han, Seung Hyeok | - |
dc.contributor.author | Oh, Yun Kyu | - |
dc.contributor.author | Park, Sue Kyung | - |
dc.contributor.author | Oh, Kook-Hwan | - |
dc.date.accessioned | 2023-01-09T00:25:20Z | - |
dc.date.available | 2023-01-09T00:25:20Z | - |
dc.date.created | 2022-11-08 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.citation | Frontiers in Nutrition, Vol.9, p. 996674 | - |
dc.identifier.issn | 2296-861X | - |
dc.identifier.uri | https://hdl.handle.net/10371/188907 | - |
dc.description.abstract | BackgroundStudies have suggested that the serum creatinine/cystatin C (Cr/CysC) ratio is a surrogate marker for muscle wasting is associated with adverse outcomes in several disease conditions. To clarify the utility of the Cr/CysC ratio as a prognostic marker in chronic kidney disease (CKD) we evaluated the association between the Cr/CysC ratio clinical outcomes in patients with non-dialysis CKD. MethodsThis prospective observational cohort study included 1,966 participants of the KoreaN cohort study Outcomes in patients With CKD (KNOW-CKD). We evaluated associated factors with the serum Cr/CysC ratio and association between the serum Cr/CysC ratio and composite outcomes of all-cause death and cardiovascular events (CVEs). ResultsThe mean age was 54 +/- 12 (SD) years and 61% were men. The mean serum Cr/CysC ratio was 10.97 +/- 1.94 in men and 9.10 +/- 1.77 in women. The Cr/CysC ratio correlated positively with urinary creatinine excretion, a marker of muscle mass. In the fully adjusted Cox proportional hazard model, the Cr/CysC ratio was associated with the occurrence of adverse outcomes through a median follow-up of 5.9 years [hazard ratio (HR) = 0.92, 95% confidence interval (CI) = 0.85-0.99 for the composite outcomes, HR = 0.87, 95% CI, 0.78 - 0.97 for all-cause death, and HR = 0.93; 95% CI, 0.84-1.04 for CVEs]. In subgroup analyses, there were interactions of the Cr/CysC ratio with age and sex for risk of the clinical outcomes, but not eGFR group. ConclusionA higher Cr/CysC ratio is associated with a lower risk of the composite outcomes, especially all-cause mortality, even after adjusting for eGFR. These suggest that the Cr/CysC ratio is a useful prognostic marker in CKD. | - |
dc.language | 영어 | - |
dc.publisher | Frontiers Media S.A. | - |
dc.title | Serum creatinine to cystatin C ratio and clinical outcomes in adults with non-dialysis chronic kidney disease | - |
dc.type | Article | - |
dc.identifier.doi | 10.3389/fnut.2022.996674 | - |
dc.citation.journaltitle | Frontiers in Nutrition | - |
dc.identifier.wosid | 000872589800001 | - |
dc.identifier.scopusid | 2-s2.0-85139718277 | - |
dc.citation.startpage | 996674 | - |
dc.citation.volume | 9 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Sue Kyung | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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