Publications
Detailed Information
External validation of the international prediction tool in Korean patients with immunoglobulin A nephropathy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Joo, Young Su | - |
dc.contributor.author | Kim, Hyung Woo | - |
dc.contributor.author | Baek, Chung Hee | - |
dc.contributor.author | Park, Jung Tak | - |
dc.contributor.author | Lee, Hajeong | - |
dc.contributor.author | Lim, Beom Jin | - |
dc.contributor.author | Yoo, Tae-Hyun | - |
dc.contributor.author | Moon, Kyung Chul | - |
dc.contributor.author | Chin, Ho Jun | - |
dc.contributor.author | Kang, Shin-Wook | - |
dc.contributor.author | Han, Seung Hyeok | - |
dc.date.accessioned | 2023-01-09T00:25:22Z | - |
dc.date.available | 2023-01-09T00:25:22Z | - |
dc.date.created | 2022-11-08 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.citation | Kidney Research and Clinical Practice, Vol.41 No.5, pp.556-566 | - |
dc.identifier.issn | 2211-9132 | - |
dc.identifier.uri | https://hdl.handle.net/10371/188909 | - |
dc.description.abstract | Background: The International IgA Nephropathy Prediction Tool has been recently developed to estimate the progression risk of im-munoglobulin A nephropathy (IgAN). This study aimed to evaluate the clinical performance of this prediction tool in a large IgAN cohort in Korea.Methods: The study cohort was comprised of 2,064 patients with biopsy-proven IgAN from four medical centers between March 2012 and September 2021. We calculated the predicted risk for each patient. The primary outcome was occurrence of a 50% decline in estimated glomerular filtration rate (eGFR) from the time of biopsy or end-stage kidney disease. The model performance was evalu-ated for discrimination, calibration, and reclassification. We also constructed and tested an additional model with a new coefficient for the Korean race.Results: During a median follow-up period of 3.8 years (interquartile range, 1.8-6.6 years), 363 patients developed the primary out-come. The two prediction models exhibited good discrimination power, with a C-statistic of 0.81. The two models generally underesti-mated the risk of the primary outcome, with lesser underestimation for the model with race. The model with race showed better per-formance in reclassification compared to the model without race (net reclassification index, 0.13). The updated model with the Kore-an coefficient showed good agreement between predicted risk and observed outcome.Conclusion: In Korean IgAN patients, International IgA Nephropathy Prediction Tool had good discrimination power but underestimat-ed the risk of progression. The updated model with the Korean coefficient showed acceptable calibration and warrants external validation. | - |
dc.language | 영어 | - |
dc.publisher | 대한신장학회 | - |
dc.title | External validation of the international prediction tool in Korean patients with immunoglobulin A nephropathy | - |
dc.type | Article | - |
dc.identifier.doi | 10.23876/j.krcp.22.006 | - |
dc.citation.journaltitle | Kidney Research and Clinical Practice | - |
dc.identifier.wosid | 000870911100005 | - |
dc.identifier.scopusid | 2-s2.0-85139150437 | - |
dc.citation.endpage | 566 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 556 | - |
dc.citation.volume | 41 | - |
dc.identifier.kciid | ART002883736 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Moon, Kyung Chul | - |
dc.contributor.affiliatedAuthor | Chin, Ho Jun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.