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Prognostic significance of BLK expression in R-CHOP treated diffuse large B-cell lymphoma
DC Field | Value | Language |
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dc.contributor.author | Choi, Soyeon | - |
dc.contributor.author | Lee, Yoo Jin | - |
dc.contributor.author | Choi, Yunsuk | - |
dc.contributor.author | Kim, Misung | - |
dc.contributor.author | Kim, Hyun-Jung | - |
dc.contributor.author | Kim, Ji Eun | - |
dc.contributor.author | Oh, Sukjoong | - |
dc.contributor.author | Chae, Seoung Wan | - |
dc.contributor.author | Cha, Hee Jeong | - |
dc.contributor.author | Jo, Jae-Cheol | - |
dc.date.accessioned | 2023-01-09T00:25:29Z | - |
dc.date.available | 2023-01-09T00:25:29Z | - |
dc.date.created | 2022-11-01 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.citation | Journal of Pathology and Translational Medicine, Vol.56 No.5, pp.281-288 | - |
dc.identifier.issn | 2383-7837 | - |
dc.identifier.uri | https://hdl.handle.net/10371/188918 | - |
dc.description.abstract | Background: The aim of the present study was to evaluate the prognostic significance of B-cell lymphocyte kinase (BLK) expression for survival outcomes in diffuse large B-cell lymphoma (DLBCL) patients treated with R-CHOP. Methods: We retrospectively analyzed the medical records of 89 patients from two tertiary referral hospitals. The expression of BLK, SYK, and CDK1 were evaluated in a semiquantitative method using an H-score, and the proportions of BCL2 and C-MYC were evaluated. Results: A total of 89 patients received R-CHOP chemotherapy as a first-line chemotherapy. The expression rates of BLK in tumor cells was 39.2% (n = 34). BLK expression status was not significantly associated with clinical variables; however, BLK expression in tumor cells was significantly associated with the expression of both C-MYC and BCL2 (p = .003). With a median follow-up of 60.4 months, patients with BLK expression had significantly lower 5-year progression-free survival (PFS) and overall survival rates (49.8% and 60.9%, respectively) than patients without BLK expression (77.3% and 86.7%, respectively). In multivariate analysis for PFS, BLK positivity was an independent poor prognostic factor (hazard ratio, 2.208; p = .040). Conclusions: Here, we describe the clinicopathological features and survival outcome according to expression of BLK in DLBCL. Approximately 39% of DLBCL patients showed BLK positivity, which was associated as a predictive marker for poor prognosis in patients who received R-CHOP chemotherapy. | - |
dc.language | 영어 | - |
dc.publisher | 대한병리학회 | - |
dc.title | Prognostic significance of BLK expression in R-CHOP treated diffuse large B-cell lymphoma | - |
dc.type | Article | - |
dc.identifier.doi | 10.4132/jptm.2022.07.26 | - |
dc.citation.journaltitle | Journal of Pathology and Translational Medicine | - |
dc.identifier.wosid | 000870477600005 | - |
dc.identifier.scopusid | 2-s2.0-85139143928 | - |
dc.citation.endpage | 288 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 281 | - |
dc.citation.volume | 56 | - |
dc.identifier.kciid | ART002876400 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Ji Eun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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