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Role of Post-translational Modification of Silent Mating Type Information Regulator 2 Homolog 1 in Cancer and Other Disorders
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yeon-Hwa | - |
dc.contributor.author | Kim, Su-Jung | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2023-01-09T02:41:09Z | - |
dc.date.available | 2023-01-09T02:41:09Z | - |
dc.date.created | 2022-11-02 | - |
dc.date.created | 2022-11-02 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.citation | 대한암예방학회지, Vol.27 No.3, pp.157-169 | - |
dc.identifier.issn | 2288-3649 | - |
dc.identifier.uri | https://hdl.handle.net/10371/188930 | - |
dc.description.abstract | Silent mating type information regulator 2 homolog 1 (SIRT1), an NAD+-dependent histone/protein deacetylase, has multifarious physiological roles in development, metabolic regulation, and stress response. Thus, its abnormal expression or malfunction is implicated in pathogenesis of various diseases. SIRT1 undergoes post-translational modifications, including phosphorylation, oxi-dation/reduction, carbonylation, nitrosylation, glycosylation, ubiquitination/deubiquitination, SUMOylation etc. which can modulate its catalytic activity, stability, subcellular localization, and also binding affinity for substrate proteins. This short review highlights the regulation of SIRT1 post-translational modifications and their pathophysiologic implications. | - |
dc.language | 영어 | - |
dc.publisher | 대한암예방학회 | - |
dc.title | Role of Post-translational Modification of Silent Mating Type Information Regulator 2 Homolog 1 in Cancer and Other Disorders | - |
dc.type | Article | - |
dc.citation.journaltitle | 대한암예방학회지 | - |
dc.identifier.wosid | 000868952700003 | - |
dc.citation.endpage | 169 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 157 | - |
dc.citation.volume | 27 | - |
dc.identifier.kciid | ART002883094 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | FATTY-ACID OXIDATION | - |
dc.subject.keywordPlus | HEPATIC STEATOSIS | - |
dc.subject.keywordPlus | PROTEIN STABILITY | - |
dc.subject.keywordPlus | O-GLCNACYLATION | - |
dc.subject.keywordPlus | CELL-SURVIVAL | - |
dc.subject.keywordPlus | SIRT1 | - |
dc.subject.keywordPlus | P53 | - |
dc.subject.keywordPlus | SUMOYLATION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | DEACETYLASE | - |
dc.subject.keywordAuthor | Post-translational modification | - |
dc.subject.keywordAuthor | Protein processing | - |
dc.subject.keywordAuthor | Sirtuin 1 | - |
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