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Bcl-6-dependent risk stratification by nuclear expression of Peli1 in diffuse large B-cell lymphoma
DC Field | Value | Language |
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dc.contributor.author | Lee, Ki Rim | - |
dc.contributor.author | Lee, Jeong-Ok | - |
dc.contributor.author | Lee, Jong Seok | - |
dc.contributor.author | Paik, Jin Ho | - |
dc.date.accessioned | 2023-01-31T06:09:39Z | - |
dc.date.available | 2023-01-31T06:09:39Z | - |
dc.date.created | 2023-01-04 | - |
dc.date.created | 2023-01-04 | - |
dc.date.created | 2023-01-04 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.citation | Journal of Cancer, Vol.13 No.14, pp.3615-3622 | - |
dc.identifier.issn | 1837-9664 | - |
dc.identifier.uri | https://hdl.handle.net/10371/189051 | - |
dc.description.abstract | Background/Aim: Peli1 is an E3 ubiquitin ligase involving lymphomagenesis by lysine 63 ubiquitination-mediated stabilization of Bcl-6 with in diffuse large B-cell lymphoma (DLBCL).Materials and Methods: We categorized nuclear expression of Peli1 according to Bcl-6 status by immunohistochemistry in DLBCL (n=100), and analyzed clinicopathologic association with prognosis.Results: We established Bcl-6/Peli1 risk model composed of high risk (Bcl-6+/Peli1+ or Bcl-6-/Peli1-; n=64) and low risk (Bcl-6+/Peli1-or Bcl-6-/Peli1+; n=36). High risk group had more frequent non-GCB subtype (83% vs 64%; p=0.033) and Bcl-6-negativity (69% vs 28%; p<0.001) than low risk group. Univariate survival analysis for progression-free survival (PFS) and overall survival (OS) revealed Bcl-6/Peli1 risk group (p=0.026 and p=0.021) and other conventional variables including international prognostic index (IPI), stage, ECOG performance status, number of extranodal sites were significant prognostic factors, along with B symptoms for OS. In multivariate analysis for PFS, Bcl-6/Peli1 risk group (p=0.032; HR=3.29), IPI (p=0.013; HR=3.39) and ECOG PS (p=0.035; HR=3.08) were independent prognostic factors. In multivariate analysis for OS, Bcl-6/Peli1 risk group (p=0.048; HR=7.87) and IPI (p=0.001; HR=12.15) were associated with prognosis.Conclusions: DLBCL had distinctive risk groups according to pairs of nuclear Peli1 and Bcl-6 expression. These results suggest the potential role of Peli1 and Bcl-6 in risk assessment in DLBCL. | - |
dc.language | 영어 | - |
dc.publisher | Ivyspring International Publisher | - |
dc.title | Bcl-6-dependent risk stratification by nuclear expression of Peli1 in diffuse large B-cell lymphoma | - |
dc.type | Article | - |
dc.identifier.doi | 10.7150/jca.67569 | - |
dc.citation.journaltitle | Journal of Cancer | - |
dc.identifier.wosid | 000891152900004 | - |
dc.identifier.scopusid | 2-s2.0-85143130245 | - |
dc.citation.endpage | 3622 | - |
dc.citation.number | 14 | - |
dc.citation.startpage | 3615 | - |
dc.citation.volume | 13 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Paik, Jin Ho | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | E3 UBIQUITIN LIGASES | - |
dc.subject.keywordPlus | BCL6 EXPRESSION | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordAuthor | malignant lymphoma | - |
dc.subject.keywordAuthor | diffuse large B-cell lymphoma | - |
dc.subject.keywordAuthor | Bcl-6 | - |
dc.subject.keywordAuthor | Peli1 | - |
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