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Significance of medication discontinuation on bisphosphonate-related jaw osteonecrosis in a rat model
DC Field | Value | Language |
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dc.contributor.author | Mustakim, Kezia Rachellea | - |
dc.contributor.author | Eo, Mi Young | - |
dc.contributor.author | Oh, Ji Hye | - |
dc.contributor.author | Lee, Ju Young | - |
dc.contributor.author | Myoung, Hoon | - |
dc.contributor.author | Kim, Soung Min | - |
dc.date.accessioned | 2023-02-03T09:05:30Z | - |
dc.date.available | 2023-02-03T09:05:30Z | - |
dc.date.created | 2022-12-27 | - |
dc.date.created | 2022-12-27 | - |
dc.date.created | 2022-12-27 | - |
dc.date.issued | 2022-12 | - |
dc.identifier.citation | Scientific Reports, Vol.12 No.1, p. 21449 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10371/189079 | - |
dc.description.abstract | © 2022. The Author(s).Bisphosphonate (BP) discontinuation has been advised as a measure to prevent the incidence of bisphosphonate-related osteonecrosis of the jaw (BRONJ), however, its efficacy remains controversial. This study aimed to analyze the efficacy of BP discontinuation in reducing BRONJ severity following tooth extraction in a rat model. Thirty-four male Sprague-Dawley rats were divided into two BRONJ model categories: oral administration (PO) of alendronate (1 mg/kg) for 3 and 8 weeks and intraperitoneal (IP) injection of pamidronate (3 mg/kg) and dexamethasone (1 mg/kg) for 20 days. The PO model was divided into five groups (a control group without BPs and four experimental groups with 1-week discontinuation). The IP model was divided into two groups consisting of group I (without discontinuation) and group II (1-week discontinuation). One molar from both sides of the mandible was extracted. After extraction, the PO models were sacrificed at 3 and 5 weeks, and the IP models were sacrificed either immediately or at 2, 4, 6, and 8 weeks. Micro-CT showed non-significant differences among PO groups but significant differences were observed between IP groups. Most bone remodeling parameters within group I of the IP model differed significantly (p-value < 0.05). Histologically, group I showed a significantly higher percentage of necrotic bone than group II (51.93 ± 12.75%, p < 0.05) and a higher number of detached osteoclasts in TRAP staining. With discontinuation of medication for at least 1 week in rats, the effects of BPs on alveolar bone are suppressed and bone turnover and osteoclast functions are restored. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Significance of medication discontinuation on bisphosphonate-related jaw osteonecrosis in a rat model | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-022-25347-3 | - |
dc.citation.journaltitle | Scientific Reports | - |
dc.identifier.wosid | 000934111100015 | - |
dc.identifier.scopusid | 2-s2.0-85143994094 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 21449 | - |
dc.citation.volume | 12 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Myoung, Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Soung Min | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SURGEONS POSITION PAPER | - |
dc.subject.keywordPlus | AMERICAN ASSOCIATION | - |
dc.subject.keywordPlus | NECROSIS | - |
dc.subject.keywordPlus | BONE | - |
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