Publications
Detailed Information
A Real-World Efficacy of Nab-Paclitaxel Monotherapy in Metastatic Breast Cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jung Sun | - |
dc.contributor.author | Suh, Koung Jin | - |
dc.contributor.author | Lee, Dae-Won | - |
dc.contributor.author | Woo, Go-Un | - |
dc.contributor.author | Kim, Miso | - |
dc.contributor.author | Kim, Se Hyun | - |
dc.contributor.author | Ryu, Han Suk | - |
dc.contributor.author | Lee, Kyung-Hun | - |
dc.contributor.author | Kim, Tae-Yong | - |
dc.contributor.author | Han, Sae-Won | - |
dc.contributor.author | Park, So Yeon | - |
dc.contributor.author | Park, In Ae | - |
dc.contributor.author | Kim, Jee Hyun | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.date.accessioned | 2023-03-20T08:42:29Z | - |
dc.date.available | 2023-03-20T08:42:29Z | - |
dc.date.created | 2022-05-25 | - |
dc.date.created | 2022-05-25 | - |
dc.date.created | 2022-05-25 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.citation | Cancer Research and Treatment, Vol.54 No.2, pp.488-496 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://hdl.handle.net/10371/189453 | - |
dc.description.abstract | Purpose We aimed to assess the real-world efficacy of nab-paclitaxel in metastatic breast cancer patients. Materials and Methods This is a retrospective study performed in two tertiary referral hospitals in Korea. Patients with metastatic breast cancer treated with nab-paclitaxel (Abraxane) between March 2016 and March 2020 were enrolled. Results A total of 102 patients with metastatic breast cancer were included. Patients were heavily pre-treated with a median of four prior lines of chemotherapy (5 lines when including endocrine therapy in hormone-receptor-positive patients), and 66 patients (64.7%) were exposed to taxanes in the metastatic setting. According to St. Gallen molecular subtypes, 36 patients (35.3%) were luminal A, 28 (27.5%) were luminal B, 18 (17.7%) were human epidermal growth factor receptor 2-positive and 20 (19.6%) had triple-negative disease. Fifty patients (49.0%) were treated with a 3-weekly regimen (260 mg/m(2) on day 1 every 3 weeks), and 52 (51.0%) were treated with a weekly regimen (100 mg/m(2) every week). Objective response rate was 22.9%. After a median follow-up of 22.0 months, median progression-free survival (PFS) was 4.0 months (95% confidence interval [CI], 2.6 to 4.8) and median overall survival was 8.7 months (95% CI, 7.5 to 11.2). Patients treated with weekly regimen had longer PFS compared to 3-weekly regimen (5.5 vs. 2.3 months, p < 0.001). Multivariate analysis revealed the treatment regimen as an independent prognostic factor for PFS. There was no grade 3 or 4 hypersensitivity reaction. Conclusion This real-world data shows that nab-paclitaxel is a reasonable treatment option in heavily pre-treated and/or taxane-exposed metastatic breast cancer patients. | - |
dc.language | 영어 | - |
dc.publisher | 대한암학회 | - |
dc.title | A Real-World Efficacy of Nab-Paclitaxel Monotherapy in Metastatic Breast Cancer | - |
dc.type | Article | - |
dc.identifier.doi | 10.4143/crt.2021.394 | - |
dc.citation.journaltitle | Cancer Research and Treatment | - |
dc.identifier.wosid | 000789993400017 | - |
dc.identifier.scopusid | 2-s2.0-85120547574 | - |
dc.citation.endpage | 496 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 488 | - |
dc.citation.volume | 54 | - |
dc.identifier.kciid | ART002830466 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lee, Dae-Won | - |
dc.contributor.affiliatedAuthor | Ryu, Han Suk | - |
dc.contributor.affiliatedAuthor | Park, So Yeon | - |
dc.contributor.affiliatedAuthor | Park, In Ae | - |
dc.contributor.affiliatedAuthor | Kim, Jee Hyun | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ALBUMIN-BOUND PACLITAXEL | - |
dc.subject.keywordPlus | PHASE-III TRIAL | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordAuthor | Albumin-bound paclitaxel | - |
dc.subject.keywordAuthor | Breast neoplasms | - |
dc.subject.keywordAuthor | Neoplasm metastasis | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.