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Pharmacological inhibition of Kv3 on oxidative stress-induced cataract progression
Cited 5 time in
Web of Science
Cited 7 time in Scopus
- Authors
- Issue Date
- 2020-12
- Publisher
- Academic Press
- Citation
- Biochemical and Biophysical Research Communications, Vol.533 No.4, pp.1255-1261
- Abstract
- Oxidative stress is one of the most important risk factors for cataractogenesis. Previous studies have indicated that BDS-II, a Kv3 channel blocker, plays pivotal roles in oxidative stress-related diseases. This study demonstrates that BDS-II exerts a protective effect on cataractogenesis. Specifically, BDS-II was observed to inhibit lens opacity induced by H2O2. BDS-II was also determined to inhibit cataract progression in a sodium selenite-induced in vivo cataract model by inhibiting reduction of the total GSH. In addition, BDS-II was demonstrated to protect human lens epithelial cells against H2O2-induced cell death. Our results suggest that BDS-II is a potential pharmacological candidate in cataract therapy.
- ISSN
- 0006-291X
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