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염산 DDB-S가 랫드의 생식독성에 미치는 영향에 관한 연구 : A Teratogenicity Study on Dimethyl Dimethoxy Biphenylate Derivative (DDB-S) in Rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김현우 | - |
dc.contributor.author | 박진홍 | - |
dc.contributor.author | 김판기 | - |
dc.contributor.author | 김준성 | - |
dc.contributor.author | 유국종 | - |
dc.contributor.author | 조현선 | - |
dc.contributor.author | 문전옥 | - |
dc.contributor.author | 박종하 | - |
dc.contributor.author | 황성희 | - |
dc.contributor.author | 이지호 | - |
dc.contributor.author | 문서현 | - |
dc.contributor.author | 김화 | - |
dc.contributor.author | 강가미 | - |
dc.contributor.author | 조명행 | - |
dc.date.accessioned | 2023-03-28T02:37:38Z | - |
dc.date.available | 2023-03-28T02:37:38Z | - |
dc.date.created | 2023-03-14 | - |
dc.date.issued | 2003-03 | - |
dc.identifier.citation | 한국독성학회지, Vol.19 No.1, pp.21-27 | - |
dc.identifier.issn | 1976-8257 | - |
dc.identifier.uri | https://hdl.handle.net/10371/189943 | - |
dc.description.abstract | A teratogenic study of dimethyl dimethoxy biphenylate derivative (DDB-S) was carriedout on Sprague-Dawley rats. DDB-S dissolved in saline was administered to male and female rats byintravenously injection at daily doses of 50 mg/kg, 75 mg/kg, and 100 mg/kg. A half of dams weresacrificed at 20th day of gestation to scrutinize the pregnant performances and fetal development.And the remaining dams were allowed to deliver. The growth, reflex, behaviour and reproductive func-tion of F1 offsprings were examined. There was no treatment-related diference in body weight, foodconsumption and necropsy findings of dams. No gross, skeletal and visceral abnormalities wasobserved in F1 fetuses from dams treated with DDB-S. F1 offsprings did not show any treatment-related diference in growth, reflex, behaviour and reproductive performance. At caesarean section ofF1 dams, no growth retardation and gross abnormality was observed in F2 fetuses. In conclusion,DDB-S did not show any potential teratogenic effect in rats. | - |
dc.language | 한국어 | - |
dc.publisher | 한국독성학회 | - |
dc.title | 염산 DDB-S가 랫드의 생식독성에 미치는 영향에 관한 연구 | - |
dc.title.alternative | A Teratogenicity Study on Dimethyl Dimethoxy Biphenylate Derivative (DDB-S) in Rats | - |
dc.type | Article | - |
dc.citation.journaltitle | 한국독성학회지 | - |
dc.citation.endpage | 27 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 21 | - |
dc.citation.volume | 19 | - |
dc.identifier.kciid | ART001211336 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | 조명행 | - |
dc.description.journalClass | 2 | - |
dc.subject.keywordAuthor | Dimethyl dimethoxy biphenylate derivative (DDB-S) | - |
dc.subject.keywordAuthor | Teratogenic study | - |
dc.subject.keywordAuthor | Rats | - |
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