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Functionalized PEG-oligo(L-lysine)-PCL micelle system for the delivery of bioactive agents based on pH-sensitive degradation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Jungkyu | - |
dc.contributor.author | Jeon, Seong Ik | - |
dc.contributor.author | Chung, In Jae | - |
dc.contributor.author | Ahn, Cheol-Hee | - |
dc.date.accessioned | 2023-04-18T06:23:14Z | - |
dc.date.available | 2023-04-18T06:23:14Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2020-12 | - |
dc.identifier.citation | Functional Composites and Structures, Vol.2 No.4, p. 045001 | - |
dc.identifier.issn | 2631-6331 | - |
dc.identifier.uri | https://hdl.handle.net/10371/190070 | - |
dc.description.abstract | Methoxy poly(ethylene glycol) amine with a molecular weight of 5 K and epsilon -caprolactone with a molecular weight of 3 K were conjugated to five lysine residues with molecular weight and M-w/M-n of 9.6 K and 1.04, respectively. The shift of peak molecular weight and narrow molecular weight distribution in a gel permeation chromatography (GPC) trace without any noticeable shoulder as well as H-1 nuclear magnetic resonance analysis confirmed the successful synthesis of the copolymer. Polymeric micelles, of size around 60 nm, were formed by dialysis and crosslinked micelles (CMs) were prepared by adding a crosslinker, terephthalaldehyde, to generate weak acid-labile benzoic-imine bonds in the interface of the micelle-forming amphiphilic copolymer. The critical micelle concentrations of non-crosslinked micelles and CMs were determined to be 4.26 x 10(-2) mg ml(-1) and 7.01 x 10(-3) mg ml(-1), respectively. The hydrolysis rate of the CMs is highly pH-dependent and much more rapid at mild acid than physiological conditions. Doxorubicin was successfully loaded into the CMs and a controlled pH-dependent release behavior was observed. The enhanced micelle stability opens a way for preparing long-circulating delivery systems encapsulating poorly water-soluble drugs. | - |
dc.language | 영어 | - |
dc.publisher | IoP Institute of Physics | - |
dc.title | Functionalized PEG-oligo(L-lysine)-PCL micelle system for the delivery of bioactive agents based on pH-sensitive degradation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1088/2631-6331/abb195 | - |
dc.citation.journaltitle | Functional Composites and Structures | - |
dc.identifier.wosid | 000648603700002 | - |
dc.identifier.scopusid | 2-s2.0-85103506982 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 045001 | - |
dc.citation.volume | 2 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Ahn, Cheol-Hee | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CROSS-LINKED MICELLES | - |
dc.subject.keywordPlus | BLOCK-COPOLYMER MICELLES | - |
dc.subject.keywordPlus | POLYMERIC MICELLES | - |
dc.subject.keywordPlus | TRIGGERED RELEASE | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | NANOSTRUCTURES | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | CARRIERS | - |
dc.subject.keywordPlus | STIMULI | - |
dc.subject.keywordAuthor | functionalized micelle | - |
dc.subject.keywordAuthor | pH-sensitive | - |
dc.subject.keywordAuthor | degradation | - |
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