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Biomaterial-based strategies to prime dendritic cell-mediated anti-cancer immune responses
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Wooram | - |
dc.contributor.author | Song, Kwang Hoon | - |
dc.contributor.author | Lim, Jaesung | - |
dc.contributor.author | Park, Chun Gwon | - |
dc.contributor.author | Doh, Junsang | - |
dc.contributor.author | Han, Dong Keun | - |
dc.date.accessioned | 2023-04-18T06:23:46Z | - |
dc.date.available | 2023-04-18T06:23:46Z | - |
dc.date.created | 2021-07-08 | - |
dc.date.created | 2021-07-08 | - |
dc.date.created | 2021-07-08 | - |
dc.date.issued | 2020-10 | - |
dc.identifier.citation | International Materials Reviews, Vol.65 No.7, pp.445-462 | - |
dc.identifier.issn | 0950-6608 | - |
dc.identifier.uri | https://hdl.handle.net/10371/190082 | - |
dc.description.abstract | Cancer immunotherapy has been extremely successful in curing patients over the last decade. Immune checkpoint blockades (ICBs) that unleash the brakes in T-cells to promote cytotoxicity against cancer cells are the most successful forms of cancer immunotherapy, yet therapeutic efficacy needs to be improved as only a fraction of patients responds. Dendritic cells (DCs) are immune cells that prime immune responses by collecting information in tumour tissues, and carrying that information to T-cells, thus delivering proper information to DCs is essential. Biomaterial-based approaches can be powerful tools for this purpose, as biomaterials allow us to deliver a variety of immunotherapeutic agents at the right time and place. Herein, we review the key concepts of cancer immunotherapy; discuss the principles for designing biomaterials to deliver immunomodulatory molecules; and outline biomaterial-based strategies to prime anti-cancer immune responses. Specifically, we focus on two widely used forms of biomaterials, multifunctional nanoparticles and biocompatible scaffolds. | - |
dc.language | 영어 | - |
dc.publisher | Maney Publishing | - |
dc.title | Biomaterial-based strategies to prime dendritic cell-mediated anti-cancer immune responses | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/09506608.2020.1735117 | - |
dc.citation.journaltitle | International Materials Reviews | - |
dc.identifier.wosid | 000520567000001 | - |
dc.identifier.scopusid | 2-s2.0-85082183530 | - |
dc.citation.endpage | 462 | - |
dc.citation.number | 7 | - |
dc.citation.startpage | 445 | - |
dc.citation.volume | 65 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Doh, Junsang | - |
dc.type.docType | Review; Early Access | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MESOPOROUS SILICA NANOPARTICLES | - |
dc.subject.keywordPlus | PHOTODYNAMIC THERAPY | - |
dc.subject.keywordPlus | GOLD NANOPARTICLES | - |
dc.subject.keywordPlus | POLYMERIC NANOPARTICLES | - |
dc.subject.keywordPlus | CHECKPOINT BLOCKADE | - |
dc.subject.keywordPlus | CANCER-THERAPY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | MULTIFUNCTIONAL NANOPARTICLES | - |
dc.subject.keywordPlus | DELIVERY-SYSTEMS | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordAuthor | Cancer immunotherapy | - |
dc.subject.keywordAuthor | biomaterials | - |
dc.subject.keywordAuthor | multifunctional nanoparticles | - |
dc.subject.keywordAuthor | biocompatible scaffolds | - |
dc.subject.keywordAuthor | priming anti-cancer immune responses | - |
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