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Unique guanidine-conjugated catechins from the leaves of Alchornea rugosa and their autophagy modulating activity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Doan, Thi-Phuong | - |
dc.contributor.author | Park, Eun-Jin | - |
dc.contributor.author | Ryu, Byeol | - |
dc.contributor.author | Cho, Hyo-Moon | - |
dc.contributor.author | Yoon, Sang -Jun | - |
dc.contributor.author | Jung, Gwan-Young | - |
dc.contributor.author | Thuong, Phuong-Thien | - |
dc.contributor.author | Oh, Won-Keun | - |
dc.date.accessioned | 2023-04-18T09:05:00Z | - |
dc.date.available | 2023-04-18T09:05:00Z | - |
dc.date.created | 2023-02-03 | - |
dc.date.created | 2023-02-03 | - |
dc.date.created | 2023-02-03 | - |
dc.date.created | 2023-02-03 | - |
dc.date.created | 2023-02-03 | - |
dc.date.issued | 2023-02 | - |
dc.identifier.citation | PHYTOCHEMISTRY, Vol.206 | - |
dc.identifier.issn | 0031-9422 | - |
dc.identifier.uri | https://hdl.handle.net/10371/190161 | - |
dc.description.abstract | Natural guanidines, molecules that contain the guanidine moiety, are structurally unique and often exhibit potent biological activities. A phytochemical investigation of the leaves of Alchornea rugosa (Lour.) Mull.Arg. by MS/MS-based molecular networking revealed eight undescribed guanidine-flavanol conjugates named rugonines A-H. The chemical structures of the isolated compounds were comprehensively elucidated by NMR spectroscopy, HRESIMS, and circular dichroism (CD) analysis. All isolated compounds were tested for autophagosome for-mation in HEK293 cells stably expressing GFP-LC3. The results revealed that compounds rugonines D-G showed potential autophagy inhibitory activity. | - |
dc.language | 영어 | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Unique guanidine-conjugated catechins from the leaves of Alchornea rugosa and their autophagy modulating activity | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.phytochem.2022.113521 | - |
dc.citation.journaltitle | PHYTOCHEMISTRY | - |
dc.identifier.wosid | 000903547200002 | - |
dc.identifier.scopusid | 2-s2.0-85144636320 | - |
dc.citation.volume | 206 | - |
dc.contributor.affiliatedAuthor | Oh, Won-Keun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MEDICINAL-PLANTS | - |
dc.subject.keywordPlus | PARASITE | - |
dc.subject.keywordPlus | MALARIA | - |
dc.subject.keywordAuthor | Alchornea rugosa | - |
dc.subject.keywordAuthor | Euphorbiaceae | - |
dc.subject.keywordAuthor | MS | - |
dc.subject.keywordAuthor | MS-based molecular networking | - |
dc.subject.keywordAuthor | Dereplication | - |
dc.subject.keywordAuthor | Guanidine-conjugated catechins | - |
dc.subject.keywordAuthor | Rugonines | - |
dc.subject.keywordAuthor | Autophagy inhibitors | - |
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