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Critical regulation of follicular helper T cell differentiation and function by Gα13 signaling : Critical regulation of follicular helper T cell differentiation and function by G alpha(13) signaling
DC Field | Value | Language |
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dc.contributor.author | Kuen, Da-Sol | - |
dc.contributor.author | Park, Miso | - |
dc.contributor.author | Ryu, Heeju | - |
dc.contributor.author | Choi, Garam | - |
dc.contributor.author | Moon, Young-Hye | - |
dc.contributor.author | Kim, Jae-Ouk | - |
dc.contributor.author | Kang, Keon Wook | - |
dc.contributor.author | Kim, Sang Geon | - |
dc.contributor.author | Chung, Yeonseok | - |
dc.date.accessioned | 2023-04-19T01:07:47Z | - |
dc.date.available | 2023-04-19T01:07:47Z | - |
dc.date.created | 2021-11-16 | - |
dc.date.created | 2021-11-16 | - |
dc.date.created | 2021-11-16 | - |
dc.date.issued | 2021-10 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America, Vol.118 No.43, p. e2108376118 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://hdl.handle.net/10371/190405 | - |
dc.description.abstract | GPCR-G alpha protein-mediated signal transduction contributes to spatiotemporal interactions between immune cells to fine-tune and facilitate the process of inflammation and host protection. Beyond this, however, how G alpha proteins contribute to the helper T cell subset differentiation and adaptive response have been underappreciated. Here, we found that G alpha 13 signaling in T cells plays a crucial role in inducing follicular helper T (Tfh) cell differentiation in vivo. T cell-specific G alpha 13-deficient mice have diminished Tfh cell responses in a cell-intrinsic manner in response to immunization, lymphocytic choriomeningitis virus infection, and allergen challenges. Moreover, G alpha 13-deficient Tfh cells express reduced levels of Bcl-6 and CXCR5 and are functionally impaired in their ability to adhere to and stimulate B cells. Mechanistically, G alpha 13-deficient Tfh cells harbor defective Rho-ROCK2 activation, and Rho agonist treatment recuperates Tfh cell differentiation and expression of Bcl-6 and CXCR5 in Tfh cells of T cell-specific G alpha 13-deficient mice. Conversely, ROCK inhibitor treatment hampers Tfh cell differentiation in wild-type mice. These findings unveil a crucial regulatory role of G alpha 13-Rho-ROCK axis in optimal Tfh cell differentiation and function, which might be a promising target for pharmacologic intervention in vaccine development as well as antibody-mediated immune disorders. | - |
dc.language | 영어 | - |
dc.publisher | National Academy of Sciences | - |
dc.title | Critical regulation of follicular helper T cell differentiation and function by Gα13 signaling | - |
dc.title.alternative | Critical regulation of follicular helper T cell differentiation and function by G alpha(13) signaling | - |
dc.type | Article | - |
dc.identifier.doi | 10.1073/pnas.2108376118 | - |
dc.citation.journaltitle | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.identifier.wosid | 000715115300009 | - |
dc.identifier.scopusid | 2-s2.0-85117384336 | - |
dc.citation.number | 43 | - |
dc.citation.startpage | e2108376118 | - |
dc.citation.volume | 118 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kang, Keon Wook | - |
dc.contributor.affiliatedAuthor | Chung, Yeonseok | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | B-CELLS | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | RHOGEF | - |
dc.subject.keywordPlus | FATE | - |
dc.subject.keywordAuthor | G& | - |
dc.subject.keywordAuthor | alpha | - |
dc.subject.keywordAuthor | (13) | - |
dc.subject.keywordAuthor | Tfh cell | - |
dc.subject.keywordAuthor | germinal center reaction | - |
dc.subject.keywordAuthor | ROCK | - |
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