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Role of dietary curcumin against waterborne lead toxicity in common carp Cyprinus carpio

Cited 17 time in Web of Science Cited 19 time in Scopus
Authors

Giri, Sib Sankar; Kim, Min Jung; Kim, Sang Guen; Kim, Sang Wha; Kang, Jeong Woo; Kwon, Jun; Lee, Sung Bin; Jung, Won Joon; Sukumaran, Venkatachalam; Park, Se Chang

Issue Date
2021-08
Publisher
Academic Press
Citation
Ecotoxicology and Environmental Safety, Vol.219, p. 112318
Abstract
Curcumin exhibited numerous key activities including antioxidant, anti-inflammatory, and immunostimulatory effects in fish. This study evaluated the protective effects of curcumin (CUR) against lead (Pb)-induced toxicities in fish. Healthy Cyprinus carpio L. individuals were segregated into control, Pb only, Pb+CUR, and CUR only groups. Pb groups were exposed to 1 mg L -1 of Pb, and CUR groups were fed a basal diet supplemented with 15 g kg 1 of CUR. After eight weeks, growth performance, Pb accumulation in tissues, various haemato-biochemical parameters, immune responses, and cytokine gene expression were measured. Dietary CUR effectively decreased Pb accumulation in tissues and increased the survival of Pb-exposed fish. Co-treatment with Pb and CUR reversed alterations in haemato-biochemical parameters, ameliorated Pb-induced oxidative stress, enhanced immune responses, and restored intestinal enzymatic activities. Dietary CUR reversed changes in intestinal microbiota in Pb-exposed fish. Pb-induced upregulation of NF-kappa Bp65 and HSP70 was inhibited by dietary CUR. CUR supplementation upregulated the mRNA levels of SOD, Nrf2, IL-10, and CYP450 1A and attenuated Pb-induced degradation of I kappa B-alpha mRNA levels. Overall, CUR antagonizes Pb-induced negative impacts in fish. Thus, dietary CUR had several beneficial effects on immune responses, decreased Pb accumulation in tissues, and reversed Pb-induced oxidative stress in fish. Therefore, CUR plays a protective role in Pb-induced immune toxicity in fish, and, as such, may be suitable as an aqua feed additive for use in carp aquaculture.
ISSN
0147-6513
URI
https://hdl.handle.net/10371/190411
DOI
https://doi.org/10.1016/j.ecoenv.2021.112318
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  • College of Veterinary Medicine
  • Department of Veterinary Medicine
Research Area Bacteriophage Therapy, Veterinary Medicine, Veterinary Microbiology

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