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Association of tumor necrosis factor-α gene promotor variant, not interleukin-10, with febrile seizures and genetic epilepsy with febrile seizure plus
DC Field | Value | Language |
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dc.contributor.author | Choi, Jieun | - |
dc.contributor.author | Choi, Sun Ah | - |
dc.contributor.author | Kim, Soo Yeon | - |
dc.contributor.author | Kim, Hunmin | - |
dc.contributor.author | Lim, Byung Chan | - |
dc.contributor.author | Hwang, Hee | - |
dc.contributor.author | Chae, Jong Hee | - |
dc.contributor.author | Kim, Ki Joong | - |
dc.contributor.author | Oh, Sohee | - |
dc.contributor.author | Shin, Jeon-Soo | - |
dc.date.accessioned | 2023-04-19T04:08:09Z | - |
dc.date.available | 2023-04-19T04:08:09Z | - |
dc.date.created | 2022-10-31 | - |
dc.date.issued | 2019-05 | - |
dc.identifier.citation | Annals of Child Neurology, Vol.27 No.2, pp.38-45 | - |
dc.identifier.issn | 2635-9103 | - |
dc.identifier.uri | https://hdl.handle.net/10371/190549 | - |
dc.description.abstract | © 2019 Korean Child Neurology Society.Purpose: Cytokines demonstrate active roles in the occurrence of febrile seizures (FS). However, whether a genetic predisposition to inflammation is implicated in FS, febrile seizure plus (FS+) or genetic epilepsy with febrile seizure plus (GEFS+) are still unclear. Therefore we perform this study to find the association of promotor variants in pro-inflammatory cytokine tumor necrosis factor-α (TNF-α) genes and anti-inflammatory cytokine interleukin 10 (IL-10) genes either with FS, FS+, and GEFS+ in Korean children. Methods: Fifty-seven children with FS, 32 FS+, and 12 GEFS+ patients were compared with 108 controls. The allelic and genotypic distributions were compared for TNF-α-238 (rs361525),-308 (rs1800629),-857 (rs1799724),-863 (rs1800630), and IL-10-592 (rs1800872),-819 (rs1800871),-1082 (rs1800896), and-1352 (rs1800893). Results: Allelic and genotypic frequencies of TNF-α and IL-10 promotor variants showed no sig-nificant differences between FS, FS+, and GEFS+ versus controls. However, AA genotypes at TNF-α-863 were present only in controls. TNF-α-863 (rs1800630) promoter variants showed an association with FS, FS+, and GEFS+ in a recessive mode of inheritance pattern (P<0.05). Conclusion: Our results suggest that AA genotypes at TNF-α-863 may be associated with FS, FS+, and GEFS+, implicating protective roles against to development of FS, FS+, and GEFS+. | - |
dc.language | 영어 | - |
dc.publisher | Korean Child Neurology Society | - |
dc.title | Association of tumor necrosis factor-α gene promotor variant, not interleukin-10, with febrile seizures and genetic epilepsy with febrile seizure plus | - |
dc.type | Article | - |
dc.identifier.doi | 10.26815/acn.2019.00038 | - |
dc.citation.journaltitle | Annals of Child Neurology | - |
dc.identifier.scopusid | 2-s2.0-85109902066 | - |
dc.citation.endpage | 45 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 38 | - |
dc.citation.volume | 27 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Choi, Jieun | - |
dc.contributor.affiliatedAuthor | Chae, Jong Hee | - |
dc.contributor.affiliatedAuthor | Kim, Ki Joong | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordAuthor | Epilepsy | - |
dc.subject.keywordAuthor | Interleukin-10 | - |
dc.subject.keywordAuthor | Seizures, febrile | - |
dc.subject.keywordAuthor | Tumor necrosis factor-alpha | - |
dc.subject.keywordAuthor | Variants | - |
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