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TIM23‐mediated insertion of transmembrane α‐helices into the mitochondrial inner membrane : TIM23-mediated insertion of transmembrane alpha-helices into the mitochondrial inner membrane

DC Field Value Language
dc.contributor.authorBotelho, Salome Calado-
dc.contributor.authorOsterberg, Marie-
dc.contributor.authorReichert, Andreas S.-
dc.contributor.authorYamano, Koji-
dc.contributor.authorBjorkholm, Patrik-
dc.contributor.authorEndo, Toshiya-
dc.contributor.authorvon Heijne, Gunnar-
dc.contributor.authorKim, Hyun-
dc.date.accessioned2023-04-19T07:01:45Z-
dc.date.available2023-04-19T07:01:45Z-
dc.date.created2021-04-12-
dc.date.created2021-04-12-
dc.date.issued2011-03-
dc.identifier.citationEMBO Journal, Vol.30 No.6, pp.1003-1011-
dc.identifier.issn0261-4189-
dc.identifier.urihttps://hdl.handle.net/10371/190757-
dc.description.abstractWhile overall hydrophobicity is generally recognized as the main characteristic of transmembrane (TM) alpha-helices, the only membrane system for which there are detailed quantitative data on how different amino acids contribute to the overall efficiency of membrane insertion is the endoplasmic reticulum (ER) of eukaryotic cells. Here, we provide comparable data for TIM23-mediated membrane protein insertion into the inner mitochondrial membrane of yeast cells. We find that hydrophobicity and the location of polar and aromatic residues are strong determinants of membrane insertion. These results parallel what has been found previously for the ER. However, we see striking differences between the effects elicited by charged residues flanking the TM segments when comparing the mitochondrial inner membrane and the ER, pointing to an unanticipated difference between the two insertion systems. The EMBO Journal (2011) 30, 1003-1011. doi:10.1038/emboj.2011.29; Published online 15 February 2011-
dc.language영어-
dc.publisherNature Publishing Group-
dc.titleTIM23‐mediated insertion of transmembrane α‐helices into the mitochondrial inner membrane-
dc.title.alternativeTIM23-mediated insertion of transmembrane alpha-helices into the mitochondrial inner membrane-
dc.typeArticle-
dc.identifier.doi10.1038/emboj.2011.29-
dc.citation.journaltitleEMBO Journal-
dc.identifier.wosid000289672900006-
dc.identifier.scopusid2-s2.0-79952744648-
dc.citation.endpage1011-
dc.citation.number6-
dc.citation.startpage1003-
dc.citation.volume30-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKim, Hyun-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusDYNAMIN-RELATED GTPASE-
dc.subject.keywordPlusGREEN FLUORESCENT PROTEINS-
dc.subject.keywordPlusENDOPLASMIC-RETICULUM-
dc.subject.keywordPlusSACCHAROMYCES-CEREVISIAE-
dc.subject.keywordPlusOLIGOSACCHARYL-TRANSFERASE-
dc.subject.keywordPlusHYDROPHOBIC DOMAIN-
dc.subject.keywordPlusMOLECULAR CODE-
dc.subject.keywordPlusIMPORT MOTOR-
dc.subject.keywordPlusFUSION-
dc.subject.keywordPlusMGM1-
dc.subject.keywordAuthorCoxVa-
dc.subject.keywordAuthormembrane protein-
dc.subject.keywordAuthorMgm1p-
dc.subject.keywordAuthormitochondria-
dc.subject.keywordAuthorTIM23-
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