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The 4-1BB ligand and 4-1BB expressed on osteoclast precursors enhance RANKL-induced osteoclastogenesis via bi-directional signaling
DC Field | Value | Language |
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dc.contributor.author | Yang, Jihyun | - |
dc.contributor.author | Park, Ok Jin | - |
dc.contributor.author | Lee, Yeon Ju | - |
dc.contributor.author | Jung, Hong-Moon | - |
dc.contributor.author | Woo, Kyung Mi | - |
dc.contributor.author | Choi, Youngnim | - |
dc.date.accessioned | 2023-04-19T07:06:04Z | - |
dc.date.available | 2023-04-19T07:06:04Z | - |
dc.date.created | 2021-04-15 | - |
dc.date.issued | 2008-06 | - |
dc.identifier.citation | European Journal of Immunology, Vol.38 No.6, pp.1598-1609 | - |
dc.identifier.issn | 0014-2980 | - |
dc.identifier.uri | https://hdl.handle.net/10371/190785 | - |
dc.description.abstract | The 4-1BB is a costimulatory molecule similar to the receptor activator of NF-kappa B ligand (RANKL), both of which are key factors for the differentiation of osteoclasts and are expressed mainly by activated T cells. The 4-1BB shares common signaling pathways with RANK, suggesting a potential role in osteoclastogenesis. In this study, the role of 4-1BB and 4-1BB ligand (4-1BBL) in osteoclastogenesis was investigated using 4-1BB(-/-) and 4-1BB(+/+) mice. osteoclast precursors normally express 4-1BB and 4-1BBL after exposure to RANKL, which was confirmed by semi-quantitative RT-PCR and flow cytometry. The 4-1BB(-/-) mice had a slightly increased bone mass accompanied by a reduced osteoclastogenic ability of 4-1BB(-/-) bone marrow-derived macrophages (BMM) ex vivo. In addition, 4-1BB(-/-) BMM demonstrated hypophosphorylation of JNK and p38 and decreased induction of c-Fos in response to RANKL stimulation. Retroviral transduction of wild-type as well as partial-length 4-1BB, which lacks TNF receptor-associated factor 2-binding sites for signaling, restored the osteoclastogenic ability of 4-1BB(-/-) BMM. Furthermore, both recombinant 4-1BB and 4-1BBL enhanced RANKL-induced osteoclastogenesis by 4-1BB(+/+) BMM and the induction of c-Fos and NFATc1.Together, these results indicate that 4-1BBL and 4-1BB expressed on osteoclast precursors enhance RANKL-induced osteoclastogenesis via bi-directional signaling, findings that may delineate the complex nature of the 4-1BBL and 4-1BB interaction. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Ltd. | - |
dc.title | The 4-1BB ligand and 4-1BB expressed on osteoclast precursors enhance RANKL-induced osteoclastogenesis via bi-directional signaling | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/eji.200737650 | - |
dc.citation.journaltitle | European Journal of Immunology | - |
dc.identifier.wosid | 000256762400014 | - |
dc.identifier.scopusid | 2-s2.0-49649122832 | - |
dc.citation.endpage | 1609 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 1598 | - |
dc.citation.volume | 38 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Woo, Kyung Mi | - |
dc.contributor.affiliatedAuthor | Choi, Youngnim | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | FACTOR-KAPPA-B | - |
dc.subject.keywordPlus | TNF RECEPTOR | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | C-FOS | - |
dc.subject.keywordPlus | MONOCYTE ACTIVATION | - |
dc.subject.keywordPlus | CD137 ILA/4-1BB | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordAuthor | 4-1BB/CD137 | - |
dc.subject.keywordAuthor | 4-1BBL | - |
dc.subject.keywordAuthor | bi-directional signaling | - |
dc.subject.keywordAuthor | osteoclastogenesis | - |
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