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Anti-inflammatory effects of BT-201, an n-butanol extract of Panax notoginseng, observed in vitro and in a collagen-induced arthritis model
DC Field | Value | Language |
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dc.contributor.author | Chang, Sun-Hwa | - |
dc.contributor.author | Choi, Youngnim | - |
dc.contributor.author | Park, Jung-Ae | - |
dc.contributor.author | Jung, Dong-Sik | - |
dc.contributor.author | Shin, Jieun | - |
dc.contributor.author | Yang, Ji-Hyun | - |
dc.contributor.author | Ko, Seon-Yle | - |
dc.contributor.author | Kim, Se-Won | - |
dc.contributor.author | Kim, Jung-Keun | - |
dc.date.accessioned | 2023-04-19T07:06:20Z | - |
dc.date.available | 2023-04-19T07:06:20Z | - |
dc.date.created | 2021-04-14 | - |
dc.date.issued | 2007-12 | - |
dc.identifier.citation | Clinical Nutrition, Vol.26 No.6, pp.785-791 | - |
dc.identifier.issn | 0261-5614 | - |
dc.identifier.uri | https://hdl.handle.net/10371/190791 | - |
dc.description.abstract | Background & aims: Although there has been some success with protein-based anti-tumor necrosis factor alpha (TNF-alpha) therapeutics, the problems associated with protein-based drugs demand alternative approaches. We screened various herbal. extracts for their ability to inhibit TNF-alpha secretions and found that BT-201, an n-butanol extract of Panax notoginseng (Burk.) F. H. Chen (P. notoginseng) has such an ability. Methods: The purpose of this study has been to evaluate the anti-inflammatory and antirheumatic effects of BT-201. The anti-inflammatory effects were evaluated by measuring the effects of BT-201 on the production of TNF-alpha, interleukin (IL)-1 ss, inducible nitric oxide (iNO), and matrix metalloproteinase- 13 (MMP-13), in vitro. The anti-rheumatic effects were evaluated by treating mice with collagen-induced arthritis (CIA) using a daily oral administration of BT-201 at 15 mg/kg/day. In addition, the effects on NF-kappa B and mitogen-activated protein kinase (MAPK) pathways were evaluated by Western blotting using phospho-specific antibodies. Results: BT-201 significantly inhibited all. the inflammatory parameters evaluated in vitro and delayed the onset and progression of CIA. BT-201 inhibited the activation of NF-kappa B, ERK, p38, and JNK pathways. Conclusions: Our results demonstrated that BT-201 can modulate various aspects of inflammation in vitro and that it has disease-modifying, anti-rheumatic effects in vivo,suggesting that it can be a potential alternative to the current anti-TNF-alpha therapeutics for rheumatoid arthritis and other inflammatory disease. (C) 2007 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Churchill Livingstone | - |
dc.title | Anti-inflammatory effects of BT-201, an n-butanol extract of Panax notoginseng, observed in vitro and in a collagen-induced arthritis model | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.clnu.2007.07.008 | - |
dc.citation.journaltitle | Clinical Nutrition | - |
dc.identifier.wosid | 000251858200015 | - |
dc.identifier.scopusid | 2-s2.0-36148941379 | - |
dc.citation.endpage | 791 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 785 | - |
dc.citation.volume | 26 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Choi, Youngnim | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | THERAPEUTIC STRATEGIES | - |
dc.subject.keywordPlus | GINSENOSIDE RB-1 | - |
dc.subject.keywordPlus | ORAL ABSORPTION | - |
dc.subject.keywordPlus | TERMINAL KINASE | - |
dc.subject.keywordPlus | DRUG-THERAPY | - |
dc.subject.keywordPlus | VIVO MODELS | - |
dc.subject.keywordPlus | DESTRUCTION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Panax notoginseng | - |
dc.subject.keywordAuthor | arthritis | - |
dc.subject.keywordAuthor | TNF-alpha | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | MAPK | - |
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