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B cells activated in the presence of Th1 cytokines inhibit osteoclastogenesis
DC Field | Value | Language |
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dc.contributor.author | Choi, Youngnim | - |
dc.contributor.author | Kim, Jeong Jae | - |
dc.date.accessioned | 2023-04-19T07:07:01Z | - |
dc.date.available | 2023-04-19T07:07:01Z | - |
dc.date.created | 2021-04-14 | - |
dc.date.issued | 2003-10 | - |
dc.identifier.citation | Experimental and Molecular Medicine, Vol.35 No.5, pp.385-392 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://hdl.handle.net/10371/190806 | - |
dc.description.abstract | Host immune response has been considered as an important disease-modifying factor of periodontitis, however, which immune cell(s) or factor(s) are involved in the destruction of periodontium remains unclear. Previously, we reported that osteoclastogenesis is enhanced by activated B cells but suppressed by activated CD8(+) T cells. We present new data that B cells activated in the presence of Th1 cytokines inhibit osteoclastogenesis. Purified murine B cells were activated with anti-IgD mAb, IL-4, and anti-CD40 mAb, in the absence (B-Th2) or presence of Th1 cytokines, either IL-2 (BIL-2) or IFN-gamma (BIFN-gamma), Each activated B cell population was co-cultured with RAW264.7 cells in the presence of soluble receptor activator of NF-kappaB ligand (sRANKL), and the effect on osteoclastic differentiation was evaluated. While B-Th2 increased osteoclastogenesis, BIL-2 and BIFN-gamma suppressed it profoundly. To verify the mediating molecule(s), we analyzed cytokine profiles of the activated B cells. Compared to B-Th2, BIL-2 expressed increased amount of IFN-gamma and BIFN-gamma expressed decreased amounts of IL-4, IL-5, and IL-10. IFN-gamma was a key negative regulator of osteoclastic differentiation, and mediated the inhibition by BIL-2. These results suggest that Th1 cytokines may have new important roles in resistance to periodontitis, acting directly on osteoclasts or indirectly through B cells. | - |
dc.language | 영어 | - |
dc.publisher | 생화학분자생물학회 | - |
dc.title | B cells activated in the presence of Th1 cytokines inhibit osteoclastogenesis | - |
dc.type | Article | - |
dc.identifier.doi | emm.2003.51 | - |
dc.citation.journaltitle | Experimental and Molecular Medicine | - |
dc.identifier.wosid | 000186884600008 | - |
dc.identifier.scopusid | 2-s2.0-0344441850 | - |
dc.citation.endpage | 392 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 385 | - |
dc.citation.volume | 35 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Choi, Youngnim | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | HUMAN PERIODONTAL-DISEASE | - |
dc.subject.keywordPlus | MOUSE MACROPHAGES | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | LYMPHOCYTE | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | POPULATIONS | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | LIGAND | - |
dc.subject.keywordPlus | OXIDE | - |
dc.subject.keywordAuthor | B lymphocyte subsets | - |
dc.subject.keywordAuthor | cytokines | - |
dc.subject.keywordAuthor | interferon type II | - |
dc.subject.keywordAuthor | interleukin-2 | - |
dc.subject.keywordAuthor | osteoclasts | - |
dc.subject.keywordAuthor | Th1 cells | - |
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