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Bacteriophage control of Pseudomonas plecoglossicida infection in ayu Plecoglossus altivelis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Se Chang | - |
dc.contributor.author | Nakai, Toshihiro | - |
dc.date.accessioned | 2023-04-19T07:07:04Z | - |
dc.date.available | 2023-04-19T07:07:04Z | - |
dc.date.created | 2021-04-15 | - |
dc.date.created | 2021-04-15 | - |
dc.date.created | 2021-04-15 | - |
dc.date.created | 2021-04-15 | - |
dc.date.issued | 2003-01 | - |
dc.identifier.citation | Diseases of Aquatic Organisms, Vol.53 No.1, pp.33-39 | - |
dc.identifier.issn | 0177-5103 | - |
dc.identifier.uri | https://hdl.handle.net/10371/190807 | - |
dc.description.abstract | Two previously isolated phages were used to examine the therapeutic effects against Pseudomonas plecoglossicida infection in ayu Plecoglossus altivelis. Phage PPp-W4 (Podoviridae) inhibited the in vitro growth of P. plecoglossicida more effectively than Phage PPpW-3 (Myoviridae), and a mixture (PPpW-3/W-4) of the 2 phages exhibited the highest inhibitory activity. In phage therapy experiments, ayu were fed P. plecoglossicida-impregnated feed (10(7) CFU fish(-1)) and then fed phage-impregnated feed (10(7) PFU fish(-1)). Mortalities of fish receiving PPpW-3, PPpW-4, PPpW-3/W4, and a control fish receiving no phages were 53.3, 40.0, 20.0 and 93.3 %, respectively. Phage (PPpW3/W-4) -receiving fish also showed high protection against water-borne infection with P. plecoglossicida. In a field trial, when phage (PPpW-3/W-4)-impregnated feed was administered to ayu in a pond where the disease occurred naturally, daily mortality of fish decreased at a constant level (5% d(-1)) to one-third after a 2 wk period. The causal relationship of phages in this phenomenon was verified by the long-lasting appearance of administered phages in the kidneys of the fish, and a disappearance of P. plecoglossicida from apparently healthy fish. Neither phage-resistant organisms nor phage-neutralizing antibodies were detected in diseased fish or apparently healthy fish, respectively. These results indicate the potential for phage control of the disease. | - |
dc.language | 영어 | - |
dc.publisher | Inter-Research Science Publishing | - |
dc.title | Bacteriophage control of Pseudomonas plecoglossicida infection in ayu Plecoglossus altivelis | - |
dc.type | Article | - |
dc.identifier.doi | 10.3354/dao053033 | - |
dc.citation.journaltitle | Diseases of Aquatic Organisms | - |
dc.identifier.wosid | 000181711500005 | - |
dc.identifier.scopusid | 2-s2.0-0037460403 | - |
dc.citation.endpage | 39 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 33 | - |
dc.citation.volume | 53 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Se Chang | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | BACTERIAL HEMORRHAGIC ASCITES | - |
dc.subject.keywordPlus | CAUSATIVE AGENT | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | CALVES | - |
dc.subject.keywordAuthor | bacteriophage | - |
dc.subject.keywordAuthor | phage therapy | - |
dc.subject.keywordAuthor | fish disease | - |
dc.subject.keywordAuthor | biological control | - |
dc.subject.keywordAuthor | Pseudomonas plecoglossicida | - |
dc.subject.keywordAuthor | Plecoglossus altivelis | - |
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