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Time trajectory of cardiac function and its relation with survival in patients with light-chain cardiac amyloidosis
DC Field | Value | Language |
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dc.contributor.author | Hwang, In-Chang | - |
dc.contributor.author | Koh, Youngil | - |
dc.contributor.author | Park, Jun-Bean | - |
dc.contributor.author | Yoon, Yeonyee E. | - |
dc.contributor.author | Kim, Hack-Lyoung | - |
dc.contributor.author | Kim, Hyung-Kwan | - |
dc.contributor.author | Kim, Yong-Jin | - |
dc.contributor.author | Cho, Goo-Yeong | - |
dc.contributor.author | Sohn, Dae-Won | - |
dc.contributor.author | Lee, Seung-Pyo | - |
dc.date.accessioned | 2023-04-19T07:09:20Z | - |
dc.date.available | 2023-04-19T07:09:20Z | - |
dc.date.created | 2021-05-17 | - |
dc.date.created | 2021-05-17 | - |
dc.date.issued | 2021-04 | - |
dc.identifier.citation | European Heart Journal Cardiovascular Imaging, Vol.22 No.4, pp.459-469 | - |
dc.identifier.issn | 2047-2404 | - |
dc.identifier.uri | https://hdl.handle.net/10371/190822 | - |
dc.description.abstract | Aims We aimed to analyse the time-serial change of cardiac function in light-chain (AL) cardiac amyloidosis patients undergoing active chemotherapy and its relationship with patient outcome. Methods and results Seventy-two patients with AL cardiac amyloidosis undergoing active chemotherapy who had two or more echocardiographic examinations were identified from a prospective observational cohort (n = 34) and a retrospective cohort (n= 38). Echocardiographic parameters were obtained immediately prior to 1-3, 3-6, 6-12, and 12-24 months after the first chemotherapy. Study endpoint was a composite of death or heart transplantation (HT). During a median of 32 months (interquartile range 8-51) follow-up, 33 patients (45.8%) died and 4 patients (5.6%) underwent HT. Echocardiograms immediately prior to the first chemotherapy did not show differences between the patients with adverse events vs. those without. Significant increase in mitral E/e' ratio and decline in left ventricular global longitudinal strain (LV-GLS) was observed, starting at 3-6 months after the first chemotherapy only in those who experienced adverse events on follow-up, which was also evident in those who responded to chemotherapy. Multivariate analysis demonstrated that B-natriuretic peptide >500 pg/mL and troponin I >0.15 ng/dL at initial diagnosis, hospitalization for heart failure, E/e' >15, and LV-GLS <10% during follow-up were independent predictors of outcome. Conclusions In AL cardiac amyloidosis patients undergoing active chemotherapy, the deterioration of LV function may occur, starting even at 3-6 months after the first chemotherapy. Serial echocardiography may help identify those who experience a clinical event in the near future despite active chemotherapy. | - |
dc.language | 영어 | - |
dc.publisher | Oxford University Press | - |
dc.title | Time trajectory of cardiac function and its relation with survival in patients with light-chain cardiac amyloidosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1093/ehjci/jeaa146 | - |
dc.citation.journaltitle | European Heart Journal Cardiovascular Imaging | - |
dc.identifier.wosid | 000637041000020 | - |
dc.identifier.scopusid | 2-s2.0-85103473565 | - |
dc.citation.endpage | 469 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 459 | - |
dc.citation.volume | 22 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Hack-Lyoung | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Jin | - |
dc.contributor.affiliatedAuthor | Cho, Goo-Yeong | - |
dc.contributor.affiliatedAuthor | Sohn, Dae-Won | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | LONGITUDINAL STRAIN | - |
dc.subject.keywordPlus | AL | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | PREDICTION | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | UPDATE | - |
dc.subject.keywordAuthor | cardiac amyloidosis | - |
dc.subject.keywordAuthor | AL amyloidosis | - |
dc.subject.keywordAuthor | light-chain amyloidosis | - |
dc.subject.keywordAuthor | global longitudinal strain | - |
dc.subject.keywordAuthor | echocardiography | - |
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