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A short C-terminal tail prevents mis-targeting of hydrophobic mitochondrial membrane proteins to the ER
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Reithinger, Johannes H. | - |
dc.contributor.author | Yim, Chewon | - |
dc.contributor.author | Park, Kwangjin | - |
dc.contributor.author | Bjorkholm, Patrik | - |
dc.contributor.author | von Heijne, Gunnar | - |
dc.contributor.author | Kim, Hyun | - |
dc.date.accessioned | 2023-04-19T07:11:02Z | - |
dc.date.available | 2023-04-19T07:11:02Z | - |
dc.date.created | 2021-05-14 | - |
dc.date.created | 2021-05-14 | - |
dc.date.issued | 2013-11 | - |
dc.identifier.citation | FEBS Letters, Vol.587 No.21, pp.3480-3486 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://hdl.handle.net/10371/190846 | - |
dc.description.abstract | Sdh3/Shh3, a subunit of mitochondrial succinate dehydrogenase, contains transmembrane domains with a hydrophobicity comparable to that of endoplasmic reticulum (ER) proteins. Here, we show that a C-terminal reporter fusion to Sdh3/Shh3 results in partial mis-targeting of the protein to the ER. This mis-targeting is mediated by the signal recognition particle (SRP) and depends on the length of the C-terminal tail. These results imply that if nuclear-encoded mitochondrial proteins contain strongly hydrophobic transmembrane domains and a long C-terminal tail, they have the potential to be recognized by SRP and mis-targeted to the ER. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | A short C-terminal tail prevents mis-targeting of hydrophobic mitochondrial membrane proteins to the ER | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.febslet.2013.08.041 | - |
dc.citation.journaltitle | FEBS Letters | - |
dc.identifier.wosid | 000325978700018 | - |
dc.identifier.scopusid | 2-s2.0-84886243535 | - |
dc.citation.endpage | 3486 | - |
dc.citation.number | 21 | - |
dc.citation.startpage | 3480 | - |
dc.citation.volume | 587 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Hyun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM | - |
dc.subject.keywordPlus | INNER MEMBRANE | - |
dc.subject.keywordPlus | SIGNAL SEQUENCE | - |
dc.subject.keywordPlus | MOLECULAR CODE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | IMPORT | - |
dc.subject.keywordPlus | TRANSLOCATION | - |
dc.subject.keywordPlus | INSERTION | - |
dc.subject.keywordPlus | PREPROTEINS | - |
dc.subject.keywordAuthor | Endoplasmic reticulum | - |
dc.subject.keywordAuthor | Mitochondria | - |
dc.subject.keywordAuthor | Signal sequence | - |
dc.subject.keywordAuthor | Co-translational translocation | - |
dc.subject.keywordAuthor | Succinate dehydrogenase | - |
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