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Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mazzucco, Anna E. | - |
dc.contributor.author | Smogorzewska, Agata | - |
dc.contributor.author | Kang, Chanhee | - |
dc.contributor.author | Luo, Ji | - |
dc.contributor.author | Schlabach, Michael R. | - |
dc.contributor.author | Xu, Qikai | - |
dc.contributor.author | Patel, Rupesh | - |
dc.contributor.author | Elledge, Stephen J. | - |
dc.date.accessioned | 2023-04-19T08:25:03Z | - |
dc.date.available | 2023-04-19T08:25:03Z | - |
dc.date.created | 2018-11-14 | - |
dc.date.created | 2018-11-14 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.citation | Genes and Development, Vol.31 No.19, pp.1933-1938 | - |
dc.identifier.issn | 0890-9369 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191075 | - |
dc.description.abstract | Senescence is a terminal differentiation program that halts the growth of damaged cells and must be circumvented for cancer to arise. Here we describe a panel of genetic screens to identify genes required for replicative senescence. We uncover a role in senescence for the potent tumor suppressor and ATM substrate USP28. USP28 controls activation of both the TP53 branch and the GATA4/NFkB branch that controls the senescence-associated secretory phenotype (SASP). These results suggest a role for ubiquitination in senescence and imply a common node downstream from ATM that links the TP53 and GATA4 branches of the senescence response. | - |
dc.language | 영어 | - |
dc.publisher | Cold Spring Harbor Laboratory Press | - |
dc.title | Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program | - |
dc.type | Article | - |
dc.identifier.doi | 10.1101/gad.304857.117 | - |
dc.citation.journaltitle | Genes and Development | - |
dc.identifier.wosid | 000414054000002 | - |
dc.identifier.scopusid | 2-s2.0-85032931142 | - |
dc.citation.endpage | 1938 | - |
dc.citation.number | 19 | - |
dc.citation.startpage | 1933 | - |
dc.citation.volume | 31 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kang, Chanhee | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ONCOGENE-INDUCED SENESCENCE | - |
dc.subject.keywordPlus | DNA-DAMAGE RESPONSE | - |
dc.subject.keywordPlus | CELLULAR SENESCENCE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | NETWORK | - |
dc.subject.keywordPlus | GENOME | - |
dc.subject.keywordAuthor | GATA4 | - |
dc.subject.keywordAuthor | senescence | - |
dc.subject.keywordAuthor | USP28 | - |
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