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Prostate-specific antigen lowering effect of metabolic syndrome is influenced by prostate volume
DC Field | Value | Language |
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dc.contributor.author | Choi, Woo Suk | - |
dc.contributor.author | Heo, Nam Ju | - |
dc.contributor.author | Paick, Jae-Seung | - |
dc.contributor.author | Son, Hwancheol | - |
dc.date.accessioned | 2023-04-19T08:59:35Z | - |
dc.date.available | 2023-04-19T08:59:35Z | - |
dc.date.created | 2018-08-27 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.citation | International Journal of Urology, Vol.23 No.4, pp.299-304 | - |
dc.identifier.issn | 0919-8172 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191246 | - |
dc.description.abstract | Objectives: To investigate the influence of metabolic syndrome on prostate-specific antigen levels by considering prostate volume and plasma volume. Methods: We retrospectively analyzed 4111 men who underwent routine check-ups including prostate-specific antigen and transrectal ultrasonography. The definition of metabolic syndrome was based on the modified Adult Treatment Panel III criteria. Prostate-specific antigen mass density (prostate-specific antigen 9 plasma volume / prostate volume) was calculated for adjusting plasma volume and prostate volume. We compared prostate-specific antigen and prostate-specific antigen mass density levels of participants with metabolic syndrome (metabolic syndrome group, n = 1242) and without metabolic syndrome (non-prostate-specific antigen metabolic syndrome group, n = 2869). To evaluate the impact of metabolic syndrome on prostate-specific antigen, linear regression analysis for the natural logarithm of prostate-specific antigen was used. Results: Patients in the metabolic syndrome group had significantly older age (P < 0.001), larger prostate volume (P < 0.001), higher plasma volume (P < 0.001) and lower mean serum prostate-specific antigen (non-metabolic syndrome group vs metabolic syndrome group; 1.22 +/- 0.91 vs 1.15 +/- 0.76 ng/mL, P = 0.006). Prostate-specific antigen mass density in the metabolic syndrome group was still significantly lower than that in the metabolic syndrome group (0.124 +/- 0.084 vs 0.115 +/- 0.071 mu g/mL, P = 0.001). After adjusting for age, prostate volume and plasma volume using linear regression model, the presence of metabolic syndrome was a significant independent factor for lower prostate-specific antigen (prostate-specific antigen decrease by 4.1%, P = 0.046). Conclusions: Prostate-specific antigen levels in patients with metabolic syndrome seem to be lower, and this finding might be affected by the prostate volume. | - |
dc.language | 영어 | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Prostate-specific antigen lowering effect of metabolic syndrome is influenced by prostate volume | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/iju.13042 | - |
dc.citation.journaltitle | International Journal of Urology | - |
dc.identifier.wosid | 000373776200002 | - |
dc.identifier.scopusid | 2-s2.0-84959137409 | - |
dc.citation.endpage | 304 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 299 | - |
dc.citation.volume | 23 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Paick, Jae-Seung | - |
dc.contributor.affiliatedAuthor | Son, Hwancheol | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | BODY-MASS INDEX | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | RISK-FACTOR | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | PROSPECTIVE COHORT | - |
dc.subject.keywordPlus | CANCER DETECTION | - |
dc.subject.keywordPlus | LIFE-STYLE | - |
dc.subject.keywordPlus | HYPERPLASIA | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | MEN | - |
dc.subject.keywordAuthor | metabolic syndrome | - |
dc.subject.keywordAuthor | prostate | - |
dc.subject.keywordAuthor | prostate-specific antigen | - |
dc.subject.keywordAuthor | prostate volume | - |
dc.subject.keywordAuthor | transrectal ultrasonography | - |
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