Publications
Detailed Information
SP, CGRP changes in pyridoxine induced neuropathic dogs with nerve growth factor gene therapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Joo-Yeon | - |
dc.contributor.author | Yoo, Dae Young | - |
dc.contributor.author | Lee, Kwon-Young | - |
dc.contributor.author | Im, Wooseok | - |
dc.contributor.author | Kim, Manho | - |
dc.contributor.author | Choi, Jung Hoon | - |
dc.contributor.author | Youn, Hwa-Young | - |
dc.contributor.author | Kim, Sae Hoon | - |
dc.contributor.author | Hwang, In Koo | - |
dc.contributor.author | Chung, Jin-Young | - |
dc.date.accessioned | 2023-04-19T09:00:19Z | - |
dc.date.available | 2023-04-19T09:00:19Z | - |
dc.date.created | 2018-08-17 | - |
dc.date.created | 2018-08-17 | - |
dc.date.created | 2018-08-17 | - |
dc.date.issued | 2016-01 | - |
dc.identifier.citation | BMC Neuroscience, Vol.17 No.1, p. 1 | - |
dc.identifier.issn | 1471-2202 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191254 | - |
dc.description.abstract | Background: Nerve growth factor (NGF) is known not only as a major factor for neuronal plasticity but also as a pain stimulator. Although there have been several trials with NGF for its application in the regeneration or protection of the nervous system, the pain induced by NGF remains a challenge to be overcome. In this study, the pain induced by NGF gene therapy was evaluated. Results: Vehicle or recombinant dog NGF plasmid was administered into the intrathecal space of dogs. Twenty-four hours after the vehicle or NGF plasmid inoculation, dogs were subcutaneously treated with 150 mg/kg pyridoxine every day for 7 days. For pain assessment, physical examination and electrophysiological recording were performed. Only in the vehicle-treated group, weight loss occurred, while NGF plasmid inoculation significantly improved this physical abnormalities. In the vehicle-treated group, electrophysiological recordings showed that H-reflex disappeared at 24 h after the last pyridoxine treatment. However, in the NGF plasmid inoculated group, the H-reflex were normal. In the results of immunohistochemistry, the NGF plasmid administration efficiently expressed in the dorsal root ganglia and significantly increased the pyridoxine-induced reduction of calcitonin gene-related peptide (CGRP) immunoreactive neurons, but not in substance P immunoreactive neurons, in the dorsal root ganglia. Conclusions: Given these results, we reason that NGF gene therapy in pyridoxine induced neuropathic dogs does not induce neuropathic pain with this dosage, even with increasing the expression of CGRP. | - |
dc.language | 영어 | - |
dc.publisher | BioMed Central | - |
dc.title | SP, CGRP changes in pyridoxine induced neuropathic dogs with nerve growth factor gene therapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s12868-015-0236-5 | - |
dc.citation.journaltitle | BMC Neuroscience | - |
dc.identifier.wosid | 000367425900001 | - |
dc.identifier.scopusid | 2-s2.0-84959074940 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 1 | - |
dc.citation.volume | 17 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Manho | - |
dc.contributor.affiliatedAuthor | Youn, Hwa-Young | - |
dc.contributor.affiliatedAuthor | Hwang, In Koo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SENSORY NEUROPATHY | - |
dc.subject.keywordPlus | BEAGLE DOGS | - |
dc.subject.keywordPlus | PAIN | - |
dc.subject.keywordPlus | NGF | - |
dc.subject.keywordPlus | HYPERALGESIA | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | PATTERN | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordAuthor | Calcitonin gene-related peptide | - |
dc.subject.keywordAuthor | Dog | - |
dc.subject.keywordAuthor | H reflex | - |
dc.subject.keywordAuthor | Nerve growth factor | - |
dc.subject.keywordAuthor | Pyridoxine | - |
dc.subject.keywordAuthor | Neuropathy | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.