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Exercise training normalizes elevated firing rate of hypothalamic presympathetic neurons in heart failure rats
DC Field | Value | Language |
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dc.contributor.author | Shen, Yiming | - |
dc.contributor.author | Park, Jin Bong | - |
dc.contributor.author | Lee, So Yeong | - |
dc.contributor.author | Han, Seong Kyu | - |
dc.contributor.author | Ryu, Pan Dong | - |
dc.date.accessioned | 2023-04-20T01:14:07Z | - |
dc.date.available | 2023-04-20T01:14:07Z | - |
dc.date.created | 2019-11-29 | - |
dc.date.created | 2019-11-29 | - |
dc.date.issued | 2019-02 | - |
dc.identifier.citation | American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol.316 No.2, pp.R110-R120 | - |
dc.identifier.issn | 0363-6119 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191295 | - |
dc.description.abstract | Exercise training (ExT) normalizes elevated sympathetic nerve activity in heart failure (HF), but the underlying mechanisms are not well understood. In this study, we examined the effects of 3 wk of ExT on the electrical activity of the hypothalamic presympathetic neurons in the brain slice of HF rats. HF rats were prepared by ligating the left descending coronary artery. The electrophysiological properties of paraventricular nucleus neurons projecting to the rostral ventrolateral medulla (PVN-RVLM) were examined using the slice patch-clamp technique. The neuronal firing rate was elevated in HF rats. and ExT induced a reduction in the firing rate (P < 0.01). This ExT-induced decrease in the firing rate was associated with an increased frequency of spontaneous and miniature inhibitory postsynaptic current (IPSCs: P < 0.05). There was no significant change in excitatory postsynaptic current. Replacing Ca2+ with Mg2+ in the recording solution reduced the elevated IPSC frequency in HF rats with ExT (P < 0.01) but not in those without ExT, indicating an increase in the probability of GABA release. In contrast, ExT did not restore the reduced GABA(A) receptor-mediated tonic inhibitory current in HF rats. A GABA(A) receptor blocker (bicuculline, 20 mu M) increased the firing rate in HF rats with ExT (P < 0.01) but not in those without ExT. Collectively, these results show that ExT normalized the elevated firing activity by increasing synaptic GABA release in PVN-RVLM neurons in HF rats. Our findings provide a brain mechanism underlying the beneficial effects of ExT in HF, which may shed light on the pathophysiology of other diseases accompanied by sympathetic hyperactivation. | - |
dc.language | 영어 | - |
dc.publisher | American Physiological Society | - |
dc.title | Exercise training normalizes elevated firing rate of hypothalamic presympathetic neurons in heart failure rats | - |
dc.type | Article | - |
dc.identifier.doi | 10.1152/ajpregu.00225.2018 | - |
dc.citation.journaltitle | American Journal of Physiology - Regulatory Integrative and Comparative Physiology | - |
dc.identifier.wosid | 000459252200004 | - |
dc.identifier.scopusid | 2-s2.0-85060529435 | - |
dc.citation.endpage | R120 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | R110 | - |
dc.citation.volume | 316 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, Jin Bong | - |
dc.contributor.affiliatedAuthor | Lee, So Yeong | - |
dc.contributor.affiliatedAuthor | Ryu, Pan Dong | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SYMPATHETIC-NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | SYNAPTIC GABA RELEASE | - |
dc.subject.keywordPlus | PROJECTING PARAVENTRICULAR NEURONS | - |
dc.subject.keywordPlus | ROSTRAL VENTROLATERAL MEDULLA | - |
dc.subject.keywordPlus | RECEPTOR-MEDIATED INHIBITION | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | ANGIOTENSIN-II | - |
dc.subject.keywordPlus | NUCLEUS NEURONS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordAuthor | IPSC | - |
dc.subject.keywordAuthor | paraventricular nucleus | - |
dc.subject.keywordAuthor | patch clamp | - |
dc.subject.keywordAuthor | rostral ventrolateral medulla | - |
dc.subject.keywordAuthor | sympathetic hyperactivation | - |
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