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An amphipathic cell penetrating peptide aids cell penetration of cyclosporin A and increases its therapeutic effect in an in vivo mouse model for dry eye disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hyun, Soonsil | - |
dc.contributor.author | Li, Lan | - |
dc.contributor.author | Yoon, Kyung Chul | - |
dc.contributor.author | Yu, Jaehoon | - |
dc.date.accessioned | 2023-04-20T01:26:13Z | - |
dc.date.available | 2023-04-20T01:26:13Z | - |
dc.date.created | 2019-12-05 | - |
dc.date.issued | 2019-11 | - |
dc.identifier.citation | Chemical Communications, Vol.55 No.91, pp.13657-13660 | - |
dc.identifier.issn | 1359-7345 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191301 | - |
dc.description.abstract | Cell penetrating peptide (CPP), LK-3, causes a ca. 10-fold increase in the cell penetration of cyclosporin A (CsA) at nanomolar concentrations. The results of an in vivo dry eye mouse model demonstrated that a 100-fold lower dose of the CsA/LK-3 complex than that of Restasis (R) is sufficient to cause the same therapeutic effect. | - |
dc.language | 영어 | - |
dc.publisher | Royal Society of Chemistry | - |
dc.title | An amphipathic cell penetrating peptide aids cell penetration of cyclosporin A and increases its therapeutic effect in an in vivo mouse model for dry eye disease | - |
dc.type | Article | - |
dc.identifier.doi | 10.1039/c9cc05960a | - |
dc.citation.journaltitle | Chemical Communications | - |
dc.identifier.wosid | 000496533500034 | - |
dc.identifier.scopusid | 2-s2.0-85074873154 | - |
dc.citation.endpage | 13660 | - |
dc.citation.number | 91 | - |
dc.citation.startpage | 13657 | - |
dc.citation.volume | 55 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Yu, Jaehoon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TOPICAL DELIVERY | - |
dc.subject.keywordPlus | ABSORPTION | - |
dc.subject.keywordPlus | CONJUGATION | - |
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