Publications
Detailed Information
Coexistence of anti-beta(2)-glycoprotein I domain I and anti-phosphatidylserine/prothrombin antibodies suggests strong thrombotic risk
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jee-Soo | - |
dc.contributor.author | Gu, JaYoon | - |
dc.contributor.author | Park, Hee Sue | - |
dc.contributor.author | Yoo, Hyun Ju | - |
dc.contributor.author | Kim, Hyun Kyung | - |
dc.date.accessioned | 2023-04-20T01:33:27Z | - |
dc.date.available | 2023-04-20T01:33:27Z | - |
dc.date.created | 2018-08-22 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.citation | Clinical Chemistry and Laboratory Medicine, Vol.55 No.6, pp.882-889 | - |
dc.identifier.issn | 1434-6621 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191313 | - |
dc.description.abstract | Background: Highly specific assays for measuring antiphospholipid antibodies (aPLs) are required for accurate assessment of thrombotic risk. aPLs against beta(2)-glycoprotein I domain I (anti-beta 2GPIdI) and against prothrombin complexed with phosphatidylserine (anti-PS/PT) have been recently identified as being associated with a hypercoagulable state. This study evaluated the synergism between anti-beta 2GPIdI and anti-PS/PT for predicting thrombotic events. Methods: A total of 180 patients with clinical suspicion of hypercoagulability were evaluated. The plasma levels of lupus anticoagulant (LA) and antibodies against anticardiolipin (anti-CL) (IgG and IgM), beta 2GPI (IgG and IgM), PS/PT (IgG and IgM), and beta 2GPI dI (IgG) were measured. Results: IgG anti-beta 2GPIdI and LA were highly associated with thrombosis. Mean values and positivity rates of IgG anti-beta 2GPI dI and IgG anti-PS/PT were significantly higher in the triple-positive group (LA+, IgG anti-CL+, IgG anti-beta 2GPI+) than in the other groups. Interestingly, the thrombotic risk [odds ratio 9OR) 24.400, 95% confidence interval (CI) 1.976-63.273, p < 0.001] of the newly defined triple positive group (LA +, IgG anti-CL +, IgG anti-beta 2GPIdI +; OR 11.182, 95% CI 1.976-63.273, p = 0.006) was more than twice that of the triple-positive group (LA +, IgG anti-CL +, IgG anti-beta 2GPI +). Double positivity for IgG anti-PS/PT and IgG anti-beta 2GPI also indicated significant thrombotic risk (OR 7.467, 95% CI 2.350-23.729, p = 0.001). Furthermore, the thrombotic risk associated with double positivity for IgG anti-PS/PT and IgG anti-beta 2GPIdI was markedly elevated (OR 33.654, 95% CI 6.322-179.141, p < 0.001). Conclusions: Our data suggest that simultaneous measurement of IgG anti-beta 2GPIdI and IgG anti-PS/PT may improve clinical decision-making for aPL-positive patients. | - |
dc.language | 영어 | - |
dc.publisher | Walter de Gruyter GmbH | - |
dc.title | Coexistence of anti-beta(2)-glycoprotein I domain I and anti-phosphatidylserine/prothrombin antibodies suggests strong thrombotic risk | - |
dc.type | Article | - |
dc.identifier.doi | 10.1515/cclm-2016-0676 | - |
dc.citation.journaltitle | Clinical Chemistry and Laboratory Medicine | - |
dc.identifier.wosid | 000400642400014 | - |
dc.identifier.scopusid | 2-s2.0-85019055739 | - |
dc.citation.endpage | 889 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 882 | - |
dc.citation.volume | 55 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Kyung | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | ANTIPHOSPHOLIPID SYNDROME | - |
dc.subject.keywordPlus | BETA2-GLYCOPROTEIN I | - |
dc.subject.keywordPlus | IGG ANTIBODIES | - |
dc.subject.keywordPlus | BETA-2-GLYCOPROTEIN-I | - |
dc.subject.keywordPlus | AUTOANTIBODIES | - |
dc.subject.keywordPlus | PROTHROMBIN | - |
dc.subject.keywordPlus | MALIGNANCIES | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | BIOMARKER | - |
dc.subject.keywordAuthor | antibodies | - |
dc.subject.keywordAuthor | antiphospholipid | - |
dc.subject.keywordAuthor | beta(2)-glycoprotein I | - |
dc.subject.keywordAuthor | phosphatidylserines | - |
dc.subject.keywordAuthor | prothrombin | - |
dc.subject.keywordAuthor | thrombosis | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.