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Preliminary Effects of Oral Uridine on the Ocular Surface in Dry Eye Patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chang, Ki Cheol | - |
dc.contributor.author | Oh, Joo Youn | - |
dc.contributor.author | In, Youn Seok | - |
dc.contributor.author | Kim, Mee Kum | - |
dc.contributor.author | Shin, Ki Cheul | - |
dc.contributor.author | Wee, Won Ryang | - |
dc.contributor.author | Lee, Jin Hak | - |
dc.contributor.author | Park, Myung Gyu | - |
dc.date.accessioned | 2023-04-26T08:08:56Z | - |
dc.date.available | 2023-04-26T08:08:56Z | - |
dc.date.created | 2023-04-26 | - |
dc.date.created | 2023-04-26 | - |
dc.date.created | 2023-04-26 | - |
dc.date.created | 2023-04-26 | - |
dc.date.created | 2023-04-26 | - |
dc.date.issued | 2009-08 | - |
dc.identifier.citation | Journal of Korean Medical Science, Vol.24 No.4, pp.701-707 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191680 | - |
dc.description.abstract | We designed a randomized, double blinded, 3-months controlled prospective clinical study to investigate effects of oral uridine on the ocular surface in dry eye patients. Twenty-seven patients who diagnosed as dry eye with lower than 5 mm of wetting in the Schirmer strip, with corneal epithelial erosion and who completely followed-up till 3 months were enrolled. Corneal-conjunctival fluorescein staining, non-anesthetic Schirmer test, impression cytology, and Ocular Surface Disease Index (OSDI) were evaluated in the experimental and placebo groups at the baseline 1 and 3 months after start of medication in a double blinded manner Fluorescein stain score of the cornea was markedly decreased in oral uridine group compared to the placebo group at 3 months after medication (P=0.032, Mann-Whitney U test). The Schirmer wetting score for the oral uridine group was significantly increased (P=0.001, Wilcoxon signed rank test) at 3 months and its difference between two groups was statistically significant (P=0.030, Mann-Whitney U test). OSDI scores were significantly decreased at 1 and 3 months in treatment group. Oral uridine is effective in treatment of dry eyes. | - |
dc.language | 영어 | - |
dc.publisher | 대한의학회 | - |
dc.title | Preliminary Effects of Oral Uridine on the Ocular Surface in Dry Eye Patients | - |
dc.type | Article | - |
dc.identifier.doi | 10.3346/jkms.2009.24.4.701 | - |
dc.citation.journaltitle | Journal of Korean Medical Science | - |
dc.identifier.wosid | 000268940300026 | - |
dc.identifier.scopusid | 2-s2.0-70350716487 | - |
dc.citation.endpage | 707 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 701 | - |
dc.citation.volume | 24 | - |
dc.identifier.kciid | ART001366272 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Oh, Joo Youn | - |
dc.contributor.affiliatedAuthor | Kim, Mee Kum | - |
dc.contributor.affiliatedAuthor | Wee, Won Ryang | - |
dc.contributor.affiliatedAuthor | Lee, Jin Hak | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | INS365 OPHTHALMIC SOLUTION | - |
dc.subject.keywordPlus | CORNEAL ENDOTHELIUM | - |
dc.subject.keywordPlus | FLUID SECRETION | - |
dc.subject.keywordPlus | P2Y(2) AGONIST | - |
dc.subject.keywordPlus | RABBIT | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | CONJUNCTIVA | - |
dc.subject.keywordAuthor | Cornea | - |
dc.subject.keywordAuthor | Dry Eye Syndromes | - |
dc.subject.keywordAuthor | Uridine | - |
dc.subject.keywordAuthor | OSDI | - |
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