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The anti-inflammatory and anti-angiogenic role of mesenchymal stem cells in corneal wound healing following chemical injury
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Joo Youn | - |
dc.contributor.author | Kim, Mee Kum | - |
dc.contributor.author | Shin, Mi Sun | - |
dc.contributor.author | Lee, Hyun Ju | - |
dc.contributor.author | Ko, Jung Hwa | - |
dc.contributor.author | Wee, Won Ryang | - |
dc.contributor.author | Lee, Jin Hak | - |
dc.date.accessioned | 2023-04-26T08:09:26Z | - |
dc.date.available | 2023-04-26T08:09:26Z | - |
dc.date.created | 2023-04-26 | - |
dc.date.created | 2023-04-26 | - |
dc.date.created | 2023-04-26 | - |
dc.date.created | 2023-04-26 | - |
dc.date.created | 2023-04-26 | - |
dc.date.issued | 2008-04 | - |
dc.identifier.citation | Stem Cells, Vol.26 No.4, pp.1047-1055 | - |
dc.identifier.issn | 1066-5099 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191690 | - |
dc.description.abstract | To investigate the anti-inflammatory and anti-angiogenic effects of mesenchymal stem cells (MSC) in the chemically burned corneas, we mechanically removed the corneal epithelium of rats after 100% alcohol instillation. The rats were then randomized into four groups: fresh media, conditioned media derived from the MSC culture (MSC-CM), MSC applied topically to the damaged corneas for 2 hours immediately after the injury or MSC-CM applied either once or 3 times per day for 3 consecutive days. Corneal surface was evaluated every week. After 3 weeks, the corneas were stained with the hematoxylineosin, and the expression of interleukin (IL)-2, interferon (IFN)-gamma, EL-6, IL-10, transforming growth factor (TGF)-beta 1, thrombospondin-1 (TSP-1), matrix metalloproteinase-2 (MMP-2), and vascular endothelial growth factor (VEGF) were analyzed. CD4(+) cells were assessed in the corneas. We found that both MSC and three-time applied MSC-CM (1) reduced corneal inflammation and neovascularization, (2) decreased IIL-2 and IEFN-gamma, although increased IIL-10 and TGF-beta 1. as well as IL-6, (3) reduced the infiltration of CD4(+) cells, and (4) upregulated the expression of TSP-1, although downregulated that of MMP-2. Interestingly, whereas three-time application of MSC-CM was partially effective, transplantation of MSC achieved a better outcome in suppressing corneal inflammation. The results of this study suggest that the anti-inflammatory and anti-angiogenic action of MSC in the chemically burned corneas might be mediated in part through paracrine pathways involving soluble factors such as IL-10, TGF-beta 1, IL-6 and TSP-1. | - |
dc.language | 영어 | - |
dc.publisher | AlphaMed Press Inc | - |
dc.title | The anti-inflammatory and anti-angiogenic role of mesenchymal stem cells in corneal wound healing following chemical injury | - |
dc.type | Article | - |
dc.identifier.doi | 10.1634/stemcells.2007-0737 | - |
dc.citation.journaltitle | Stem Cells | - |
dc.identifier.wosid | 000255000000022 | - |
dc.identifier.scopusid | 2-s2.0-49249129381 | - |
dc.citation.endpage | 1055 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 1047 | - |
dc.citation.volume | 26 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Oh, Joo Youn | - |
dc.contributor.affiliatedAuthor | Kim, Mee Kum | - |
dc.contributor.affiliatedAuthor | Wee, Won Ryang | - |
dc.contributor.affiliatedAuthor | Lee, Jin Hak | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | CYTOKINE EXPRESSION | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | THROMBOSPONDIN-1 | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | INHIBIT | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | NEOVASCULARIZATION | - |
dc.subject.keywordPlus | ENGRAFTMENT | - |
dc.subject.keywordAuthor | angiogenesis | - |
dc.subject.keywordAuthor | cornea | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | mesenchymal stem cell | - |
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