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The Effect of miR-146a on the Gene Expression of Immunoregulatory Cytokines in Human Mesenchymal Stromal Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ko, Jung Hwa | - |
dc.contributor.author | Oh, Joo Youn | - |
dc.date.accessioned | 2023-04-28T06:56:45Z | - |
dc.date.available | 2023-04-28T06:56:45Z | - |
dc.date.created | 2020-11-10 | - |
dc.date.created | 2020-11-10 | - |
dc.date.created | 2020-11-10 | - |
dc.date.created | 2020-11-10 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.citation | International Journal of Molecular Sciences, Vol.21 No.18, pp.6809-9 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191714 | - |
dc.description.abstract | Mounting evidence indicates that microRNAs (miRNAs), including miR-146a, have an impact on the immunomodulatory activities of mesenchymal stem/stromal cells (MSCs). Suppression of inflammatory macrophage activation is one of the main immunomodulatory mechanisms of MSCs. Here, we investigated whether miR-146a in MSCs might play a role in the effects of MSCs on macrophage activation. A miRNA microarray revealed that miR-146a was the most highly upregulated miRNA in MSCs upon co-culture with activated macrophages. Inhibition of miR-146a in MSCs through miR-146a inhibitor transfection had a different effect on the expression of immunoregulatory factors secreted by MSCs. Pentraxin 3, tumor necrosis factor-inducible gene 6, and cyclooxygenase-2, which are well-known mediators of the immunomodulatory functions of MSCs, were significantly upregulated in MSCs after miR-146a knockdown. By contrast, hepatocyte growth factor and stanniocalcin 1, other immunoregulatory molecules expressed by MSCs, were downregulated by miR-146a knockdown. Consequently, the inhibition of miR-146a in MSCs did not change the overall effect of MSCs on the suppression of inflammatory macrophage activation or the induction of anti-inflammatory macrophage polarization. | - |
dc.language | 영어 | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | The Effect of miR-146a on the Gene Expression of Immunoregulatory Cytokines in Human Mesenchymal Stromal Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ijms21186809 | - |
dc.citation.journaltitle | International Journal of Molecular Sciences | - |
dc.identifier.wosid | 000581663900001 | - |
dc.identifier.scopusid | 2-s2.0-85090906397 | - |
dc.citation.endpage | 9 | - |
dc.citation.number | 18 | - |
dc.citation.startpage | 6809 | - |
dc.citation.volume | 21 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Oh, Joo Youn | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordPlus | MSCS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | SECRETE | - |
dc.subject.keywordAuthor | immunoregulatory factor | - |
dc.subject.keywordAuthor | macrophage | - |
dc.subject.keywordAuthor | mesenchymal stem | - |
dc.subject.keywordAuthor | stromal cell | - |
dc.subject.keywordAuthor | microRNA | - |
dc.subject.keywordAuthor | miR-146a | - |
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