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Cross-talk between human mesenchymal stem/progenitor cells (MSCs) and rat hippocampal slices in LPS-stimulated cocultures: The MSCs are activated to secrete prostaglandin E2
Cited 30 time in
Web of Science
Cited 26 time in Scopus
- Authors
- Issue Date
- 2011-12
- Publisher
- Blackwell Publishing Inc.
- Citation
- Journal of Neurochemistry, Vol.119 No.5, pp.1052-1063
- Abstract
- Mesenchymal stem/progenitor cells (MSCs) improve functional outcome in a number of disease models through suppression of inflammation. However, their effects on neuroinflammation are unknown. In this study, we show that MSCs suppress endotoxin-induced glial activation in organotypic hippocampal slice cultures (OHSCs). Lipopolysaccharide-stimulated OHSCs activated MSCs to increase the expression of cyclo-oxygenase-2 and produce prostaglandin E2. MSC-derived prostaglandin E2, then suppressed pro-inflammatory cytokine production by the OHSCs. Together, the results suggest the potential anti-inflammatory mechanism of MSCs in models of disease and support earlier observations that MSCs may offer a therapy for neuroinflammation produced by trauma or disease. © 2011 The Authors. Journal of Neurochemistry © 2011 International Society for Neurochemistry.
- ISSN
- 0022-3042
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