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Investigating the relationship between serum interleukin-17 levels and systemic immune-mediated disease in patients with dry eye syndrome.
DC Field | Value | Language |
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dc.contributor.author | Oh, Joo Youn | - |
dc.contributor.author | Kim, Mee Kum | - |
dc.contributor.author | Choi, Hyuk Jin | - |
dc.contributor.author | Ko, Jung Hwa | - |
dc.contributor.author | Kang, Eun Joo | - |
dc.contributor.author | Lee, Hyun Ju | - |
dc.contributor.author | Wee, Won Ryang | - |
dc.contributor.author | Lee, Jin Hak | - |
dc.date.accessioned | 2023-04-28T06:57:40Z | - |
dc.date.available | 2023-04-28T06:57:40Z | - |
dc.date.created | 2023-04-26 | - |
dc.date.created | 2023-04-26 | - |
dc.date.issued | 2011-04 | - |
dc.identifier.citation | Korean Journal of Ophthalmology, Vol.25 No.2, pp.73-76 | - |
dc.identifier.issn | 1011-8942 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191733 | - |
dc.description.abstract | To investigate the association between dry eye syndrome (DE) and serum levels of interleukin (IL)-17 in patients with systemic immune-mediated diseases. IL-17 and IL-23 levels were measured in the sera of patients whose tear production was <5 mm on the Schirmer test. Subjects included patients with chronic graft-versus-host disease (GVHD), rheumatoid arthritis (RA), Sjogren's syndrome (SS), systemic lupus erythematosus (SLE), and no systemic disease. Corneal/conjunctival fluorescein staining was scored and the correlation between the score and the IL-17 level was evaluated. A strong correlation existed between IL-17 level and the type of systemic disease. IL-17 was significantly elevated in patients with chronic GVHD compared to those with RA and SS. IL-17 was not detectable in patients with SLE or in those without systemic disease. IL-23 was not detected in any of the subjects. IL-17 was significantly increased in patients with high fluorescein staining scores. Our data suggest that IL-17 is involved in the pathogenesis of DE in patients with systemic immune-mediated diseases. © 2011 The Korean Ophthalmological Society | - |
dc.language | 영어 | - |
dc.publisher | 대한안과학회 | - |
dc.title | Investigating the relationship between serum interleukin-17 levels and systemic immune-mediated disease in patients with dry eye syndrome. | - |
dc.type | Article | - |
dc.identifier.doi | 10.3341/kjo.2011.25.2.73 | - |
dc.citation.journaltitle | Korean Journal of Ophthalmology | - |
dc.identifier.scopusid | 2-s2.0-79960147535 | - |
dc.citation.endpage | 76 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 73 | - |
dc.citation.volume | 25 | - |
dc.identifier.kciid | ART001542387 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Oh, Joo Youn | - |
dc.contributor.affiliatedAuthor | Kim, Mee Kum | - |
dc.contributor.affiliatedAuthor | Wee, Won Ryang | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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