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The Anti-inflammatory Effect of Subconjunctival Bevacizumab on Chemically Burned Rat Corneas
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Joo Youn | - |
dc.contributor.author | Kim, Mee Kum | - |
dc.contributor.author | Shin, Mi Sun | - |
dc.contributor.author | Lee, Hyun Ju | - |
dc.contributor.author | Lee, Jin Hak | - |
dc.contributor.author | Wee, Won Ryang | - |
dc.date.accessioned | 2023-04-28T06:57:57Z | - |
dc.date.available | 2023-04-28T06:57:57Z | - |
dc.date.created | 2023-04-26 | - |
dc.date.issued | 2009-02 | - |
dc.identifier.citation | Current Eye Research, Vol.34 No.2, pp.85-91 | - |
dc.identifier.issn | 0271-3683 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191739 | - |
dc.description.abstract | Purpose: To investigate the effect of bevacizumab in a model of corneal inflammation. Materials and Methods: Epithelium from the cornea and limbus was completely removed using 100% alcohol in rats. Bevacizumab (1.25 mg/0.05 ml) or normal saline was subconjunctivally injected. One week later, corneas were examined and subjected to hematoxylin-eosin and immunofluorescent staining for VEGF. Expression of IL-2, IFN-, IL-6, and TGF- 1 were analyzed by ELISA. Results: Bevacizumab showed a borderline reduction in corneal neovascularization (11.0 4.8% and 18.0 10.0% in the bevacizumab and control groups, respectively; p = 0.054), while the extent of epithelialization was not affected (5.0 3.4% and 6.1 5.2% in the bevacizumab and control groups, respectively; p = 0.715). The infiltration of inflammatory cells was reduced (99.3 22.3 cells/ 400 in the bevacizumab-injected corneas and 182.3 58.0 cells/ 400 in the controls; p = 0.013). The levels of IL-2, IFN-, and IL-6 were decreased in the rats with the bevacizumab injections (44 6 and 79 9 pg/ml for IL-2 in the bevacizumab-injected group and control, respectively, p = 0.025; 45 5 and 67 6 pg/ml for IFN- in the bevacizumab-injected group and controls, respectively, p = 0.043; 45 6 and 75 8 pg/ml for IL-6 in the bevacizumab-injected group and controls, respectively, p = 0.030). Conclusions: Bavacizumab showed a reduction in inflammatory cell infiltration and cytokines in chemically burned rat corneas. | - |
dc.language | 영어 | - |
dc.publisher | Swets & Zeitlinger | - |
dc.title | The Anti-inflammatory Effect of Subconjunctival Bevacizumab on Chemically Burned Rat Corneas | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/02713680802607740 | - |
dc.citation.journaltitle | Current Eye Research | - |
dc.identifier.wosid | 000263366800001 | - |
dc.identifier.scopusid | 2-s2.0-60749092838 | - |
dc.citation.endpage | 91 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 85 | - |
dc.citation.volume | 34 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Oh, Joo Youn | - |
dc.contributor.affiliatedAuthor | Kim, Mee Kum | - |
dc.contributor.affiliatedAuthor | Lee, Jin Hak | - |
dc.contributor.affiliatedAuthor | Wee, Won Ryang | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MACULAR EDEMA | - |
dc.subject.keywordPlus | INTRAVITREAL BEVACIZUMAB | - |
dc.subject.keywordPlus | NEOVASCULARIZATION | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | LYMPHANGIOGENESIS | - |
dc.subject.keywordPlus | AVASTIN | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | angiogenesis | - |
dc.subject.keywordAuthor | bevacizumab | - |
dc.subject.keywordAuthor | cornea | - |
dc.subject.keywordAuthor | epithelium | - |
dc.subject.keywordAuthor | inflammation | - |
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