Selective C–H fluoroalkylation of azines enabled by tailored phosphorus-based reagents

Abstract

The installation of -CF3 or -CF2H groups into compounds can impact important biologically relevant properties. In a recent paper published in Nature, McNally, Paton, and co-workers introduce novel phosphine-based reagents that allow for the conversion of a variety of complex azines through C-H functionalization directly into their fluoroalkylated derivatives.