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Estrogen receptor α as a predictive biomarker for survival in human papillomavirus-positive oropharyngeal squamous cell carcinoma : Estrogen receptor alpha as a predictive biomarker for survival in human papillomavirus-positive oropharyngeal squamous cell carcinoma
DC Field | Value | Language |
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dc.contributor.author | Kwon, Soohyeon | - |
dc.contributor.author | Ahn, Soon-Hyun | - |
dc.contributor.author | Jeong, Woo-Jin | - |
dc.contributor.author | Jung, Young-Ho | - |
dc.contributor.author | Jung, Yun | - |
dc.contributor.author | Paik, Jin Ho | - |
dc.contributor.author | Chung, Jin-Haeng | - |
dc.contributor.author | Kim, Hyojin | - |
dc.date.accessioned | 2023-05-08T00:34:02Z | - |
dc.date.available | 2023-05-08T00:34:02Z | - |
dc.date.created | 2020-07-14 | - |
dc.date.created | 2020-07-14 | - |
dc.date.created | 2020-07-14 | - |
dc.date.issued | 2020-06 | - |
dc.identifier.citation | Journal of Translational Medicine, Vol.18 No.1, p. 240 | - |
dc.identifier.issn | 1479-5876 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191891 | - |
dc.description.abstract | Background Although oropharyngeal squamous cell carcinoma (OPSCC) with human papillomavirus (HPV) infection has a good prognosis, the accurate prediction of survival and risk of treatment failure is essential to design deintensification regimens. Here, we investigated estrogen receptor alpha (ER alpha) as a prognostic biomarker with therapeutic implications in OPSCC alongside factors associated with HPV infection. Methods We performed immunohistochemistry for ER alpha and p53 using formalin-fixed, paraffin-embedded tissues and assessed the HPV status using p16 immunohistochemistry and HPV DNA testing in 113 consecutive patients with OPSCC treated with surgical resection or radiotherapy/chemoradiotherapy. Results ER alpha expression and p53 alteration was observed in 35.4% and 21.2% OPSCCs; 45.6% and 1.3% p16+/HPV+ OPSCCs; and 11.5% and 76.9% p16- OPSCCs, respectively. These data suggest that OPSCC pathogenesis varies with HPV status. Furthermore, ER alpha expression was associated with improved overall survival (OS) in both HPV+ (p16+/HPV+ OPSCC) and p16+ (p16+ OPSCC irrespective of HPV status) models (p = 0.005 andp = 0.006, respectively) and with improved OS adjusted for stage (p = 0.037, hazard ratio: 0.109, 95% confidence interval 0.013-0.871) in the p16+ model. Conclusions ER alpha is a potential predictive biomarker for improved survival in both HPV+ and p16+ OPSCC models. | - |
dc.language | 영어 | - |
dc.publisher | BioMed Central | - |
dc.title | Estrogen receptor α as a predictive biomarker for survival in human papillomavirus-positive oropharyngeal squamous cell carcinoma | - |
dc.title.alternative | Estrogen receptor alpha as a predictive biomarker for survival in human papillomavirus-positive oropharyngeal squamous cell carcinoma | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s12967-020-02396-8 | - |
dc.citation.journaltitle | Journal of Translational Medicine | - |
dc.identifier.wosid | 000542762500002 | - |
dc.identifier.scopusid | 2-s2.0-85086686864 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 240 | - |
dc.citation.volume | 18 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Paik, Jin Ho | - |
dc.contributor.affiliatedAuthor | Chung, Jin-Haeng | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CERVICAL-CANCER | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | TP53 MUTATION | - |
dc.subject.keywordPlus | HEAD | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | Estrogen receptor alpha | - |
dc.subject.keywordAuthor | Oropharynx | - |
dc.subject.keywordAuthor | Squamous cell carcinoma | - |
dc.subject.keywordAuthor | Human papillomavirus | - |
dc.subject.keywordAuthor | Biomarker | - |
dc.subject.keywordAuthor | Prognosis | - |
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