Potential oncogenic role and prognostic implication of microRNA-155-5p in oral squamous cell carcinoma

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Kim, Hyojin; Yang, Jeong Mi; Ahn, Soon-Hyun; Jeong, Woo-Jin; Chung, Jin-Haeng; Paik, Jin Ho

Issue Date
International Institute of Anticancer Research
Anticancer Research, Vol.38 No.9, pp.5193-5200
Background: Altered microRNA expression is associated with cancer progression. This study investigated the prognostic significance of microRNA-155-5p (miR-155-5p), a well-known oncomiR, in oral squamous cell carcinoma (OSCC). Materials and Methods: miR-155-5p expression was assessed using quantitative reverse-transcription polymerase chain reaction in 68 formalin-fixed, paraffin-embedded OSCC specimens. E-Cadherin immunohistochemistry was conducted to correlate epithelial-mesenchymal transition (EMT) with miR- 155-5p expression. Results: Elevated miR-155-5p was associated with higher pathological TNM stage (p=0.048) and relapse (p=0.029). High miR-155-5p expression, along with angiolymphatic invasion and advanced stage, was a statistically significant prognostic factor for poorer diseasefree survival. In patients with stage I-II disease, high miR-155-5p was the only significant prognostic factor (p=0.033). A significant negative correlation was observed between miR-155-5p and E-cadherin expression (p=0.015), suggesting a possible role for miR-155-5p in EMT. Conclusion: miR-155-5p expression might contribute to EMT-associated OSCC progression and serve as a biomarker for predicting relapse, especially for patients with early-stage OSCC.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
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