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Clinicopathologic implication of microRNA-197 in diffuse large B cell lymphoma
DC Field | Value | Language |
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dc.contributor.author | Yang, Jeong Mi | - |
dc.contributor.author | Jang, Ji-Young | - |
dc.contributor.author | Jeon, Yoon Kyung | - |
dc.contributor.author | Paik, Jin Ho | - |
dc.date.accessioned | 2023-05-08T00:36:12Z | - |
dc.date.available | 2023-05-08T00:36:12Z | - |
dc.date.created | 2019-07-09 | - |
dc.date.created | 2019-07-09 | - |
dc.date.created | 2019-07-09 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.citation | Journal of Translational Medicine, Vol.16 No.1, p. 162 | - |
dc.identifier.issn | 1479-5876 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191935 | - |
dc.description.abstract | Background: Diffuse large B cell lymphoma (DLBCL) contains heterogeneous subtypes with various molecular dysregulation at the gene, protein and microRNA levels. Compared with the GCB subtype, the non-germinal center B-like (non-GCB)/activated B cell-like (ABC) subtype exhibits frequent progression despite standard immunochemotherapy. We aimed to investigate the effects of miR-197 on the progression and chemosensitivity of DLBCL with respect to the GCB and non-GCB/ABC subtypes. Methods: To screen distinctively expressed microRNAs, microRNA expression patterns were analyzed in 10 DLBCL cases by microarray chip assays. Using quantitative real-time polymerase chain reaction (qRT-PCR), associations between miR-197 expression levels and clinicopathologic variables were investigated in 51 DLBCL tissue samples. The effects of miR-197 on doxorubicin chemosensitivity were investigated using the OCI-Ly1 and SUDHL9 cell lines. Results: MicroRNA expression profiling by hierarchical clustering revealed that miR-197 was one of the distinctively expressed microRNAs in DLBCL. Quantitative analysis using qRT-PCR revealed that miR-197 levels were not correlated with clinicopathologic variables, including the international prognostic index, but low miR-197 levels were significantly associated with lymphoma progression defined by refractoriness, relapse or death in the rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP)-treated subgroup (n = 43; p = 0.004). Among the three molecular groups, i.e., the GCB, non-GCB/miR-197(low) and non-GCB/miR-197(high) groups, progression was most frequently observed in the non-GCB/miR-197(low) group in the full cohort (p = 0.013) and the R-CHOP cohort (p = 0.008). In survival analysis, low miR-197 levels were independently predictive of shorter progression-free survival in the R-CHOP cohort (p = 0.031; HR = 27.9) and the non-GCB subgroup (p = 0.037; HR = 21.5) but not in the GCB subgroup. Using SUDHL9 (ABC type) and OCI-Ly1 (GCB type) cells, the effects of doxorubicin on reducing cell viability were enhanced by miR-197 transfection. In apoptosis assays, miR-197 transfection enhanced doxorubicin-induced apoptosis in SUDHL9 cells but not in OCI-Ly1 cells, suggesting a chemosensitizing effect of miR-197 in ABC DLBCL. Conclusions: These results suggest the role of miR-197 as a biomarker with potential therapeutic implications. | - |
dc.language | 영어 | - |
dc.publisher | BioMed Central | - |
dc.title | Clinicopathologic implication of microRNA-197 in diffuse large B cell lymphoma | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s12967-018-1537-0 | - |
dc.citation.journaltitle | Journal of Translational Medicine | - |
dc.identifier.wosid | 000434981200001 | - |
dc.identifier.scopusid | 2-s2.0-85048342863 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 162 | - |
dc.citation.volume | 16 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Jeon, Yoon Kyung | - |
dc.contributor.affiliatedAuthor | Paik, Jin Ho | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NON-HODGKINS-LYMPHOMA | - |
dc.subject.keywordPlus | MOLECULAR SUBTYPES | - |
dc.subject.keywordPlus | MULTIPLE-MYELOMA | - |
dc.subject.keywordPlus | DRUG DOXORUBICIN | - |
dc.subject.keywordPlus | ELDERLY-PATIENTS | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordAuthor | microRNA | - |
dc.subject.keywordAuthor | miR-197 | - |
dc.subject.keywordAuthor | Diffuse large B cell lymphoma | - |
dc.subject.keywordAuthor | Chemosensitivity | - |
dc.subject.keywordAuthor | Apoptosis | - |
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