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Clinicopathological categorization of Epstein-Barr virus-positive T/NK-cell lymphoproliferative disease: an analysis of 42 cases with an emphasis on prognostic implications : Clinicopathological categorization of Epstein–Barr virus-positive T/NK-cell lymphoproliferative disease: an analysis of 42 cases with an emphasis on prognostic implications
DC Field | Value | Language |
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dc.contributor.author | Paik, Jin Ho | - |
dc.contributor.author | Choe, Ji-Young | - |
dc.contributor.author | Kim, Hyojin | - |
dc.contributor.author | Lee, Jeong-Ok | - |
dc.contributor.author | Kang, Hyoung Jin | - |
dc.contributor.author | Shin, Hee Young | - |
dc.contributor.author | Lee, Dong Soon | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.contributor.author | Kim, Chul-Woo | - |
dc.contributor.author | Cho, Kwang-Hyun | - |
dc.contributor.author | Kim, Tae Min | - |
dc.contributor.author | Jeon, Yoon Kyung | - |
dc.date.accessioned | 2023-05-08T00:41:35Z | - |
dc.date.available | 2023-05-08T00:41:35Z | - |
dc.date.created | 2018-06-01 | - |
dc.date.created | 2018-06-01 | - |
dc.date.issued | 2017-01 | - |
dc.identifier.citation | Leukemia and Lymphoma, Vol.58 No.1, pp.53-63 | - |
dc.identifier.issn | 1042-8194 | - |
dc.identifier.uri | https://hdl.handle.net/10371/191962 | - |
dc.description.abstract | Epstein-Barr virus-positive T/NK-cell lymphoproliferative diseases (EBV-T/NK-LPDs) include several overlapping EBV-related conditions with variably aggressive courses. For prognostic categorization, we retrospectively analyzed 42 EBV-T/NK-LPD cases. Male (79% [33/42]), young (<= 40 years; 83% [35/42]) patients and T-cell lineage (81% [34/42]; CD8/CD4 = 1.8) were predominant. Clinicopathologically, three systemic and one cutaneous category were developed: hemophagocytic lymphohistiocytosis (HLH; 26% [11/42]), chronic active EBV infection (CAEBV; 31% [13/42]), systemic unclassifiable disease (24% [10/42]), and hydroa vacciniforme/hydroa vacciniforme-like lymphoma (HV/HVL; 19% [8/42]). Prognostically, cutaneous disease (HV/HVL) was better than systemic disease (p = 0.014; median, 285 vs. 10 months). In systemic diseases, HLH was worst (p = 0.002; 3[HLH] vs. 4[unclassifiable] vs. not reached [CAEBV]). Univariate survival analysis (n = 42) revealed cytopenia (>= one lineage; p<0.001), onset age (>40 years; p = 0.001), T-cell lineage (p = 0.041), hemophagocytic histiocytes (p = 0.031), elevated lactate dehydrogenase (p = 0.020), and liver dysfunction (p = 0.023) predicted shorter survival. In multivariate analysis, T-cell lineage (p = 0.025 [HR = 11.3]) and cytopenia (p = 0.028 [HR = 5.4]) were independent prognostic factors. Therefore, EBV-T/NK-LPD could be classified into four prognostic categories. | - |
dc.language | 영어 | - |
dc.publisher | Taylor & Francis | - |
dc.title | Clinicopathological categorization of Epstein-Barr virus-positive T/NK-cell lymphoproliferative disease: an analysis of 42 cases with an emphasis on prognostic implications | - |
dc.title.alternative | Clinicopathological categorization of Epstein–Barr virus-positive T/NK-cell lymphoproliferative disease: an analysis of 42 cases with an emphasis on prognostic implications | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/10428194.2016.1179297 | - |
dc.citation.journaltitle | Leukemia and Lymphoma | - |
dc.identifier.wosid | 000387484400009 | - |
dc.identifier.scopusid | 2-s2.0-84966710345 | - |
dc.citation.endpage | 63 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 53 | - |
dc.citation.volume | 58 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Paik, Jin Ho | - |
dc.contributor.affiliatedAuthor | Kang, Hyoung Jin | - |
dc.contributor.affiliatedAuthor | Shin, Hee Young | - |
dc.contributor.affiliatedAuthor | Lee, Dong Soon | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.contributor.affiliatedAuthor | Kim, Chul-Woo | - |
dc.contributor.affiliatedAuthor | Cho, Kwang-Hyun | - |
dc.contributor.affiliatedAuthor | Jeon, Yoon Kyung | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ACTIVE EBV INFECTION | - |
dc.subject.keywordPlus | HYDROA VACCINIFORME | - |
dc.subject.keywordPlus | NONIMMUNOCOMPROMISED HOSTS | - |
dc.subject.keywordPlus | CHILDHOOD | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordPlus | DISORDER | - |
dc.subject.keywordAuthor | Chronic active EBV infection | - |
dc.subject.keywordAuthor | EBV-positive T/NK-cell lymphoproliferative disorder | - |
dc.subject.keywordAuthor | Epstein-Barr virus | - |
dc.subject.keywordAuthor | hydroa vacciniforme-like lymphoma | - |
dc.subject.keywordAuthor | systemic EBV-positive T-cell lymphoproliferative disease of childhood | - |
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