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Discordance between anaplastic lymphoma kinase status in primary non-small-cell lung cancers and their corresponding metastases
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyojin | - |
dc.contributor.author | Xu, Xianhua | - |
dc.contributor.author | Yoo, Seol-Bong | - |
dc.contributor.author | Sun, Ping-Li | - |
dc.contributor.author | Jin, Yan | - |
dc.contributor.author | Paik, Jin Ho | - |
dc.contributor.author | Choe, Gheeyoung | - |
dc.contributor.author | Jheon, Sanghoon | - |
dc.contributor.author | Lee, Choon-Taek | - |
dc.contributor.author | Chung, Jin-Haeng | - |
dc.date.accessioned | 2023-05-08T00:49:56Z | - |
dc.date.available | 2023-05-08T00:49:56Z | - |
dc.date.created | 2020-07-10 | - |
dc.date.created | 2020-07-10 | - |
dc.date.issued | 2013-01 | - |
dc.identifier.citation | Histopathology, Vol.62 No.2, pp.305-314 | - |
dc.identifier.issn | 0309-0167 | - |
dc.identifier.uri | https://hdl.handle.net/10371/192074 | - |
dc.description.abstract | Kim H, Xu X, Yoo S-B, Sun P-L, Jin Y, Paik J H, Choe G, Jheon S, Lee C-T & Chung J-H (2013) Histopathology 62, 305-314 Discordance between anaplastic lymphoma kinase status in primary non-small-cell lung cancers and their corresponding metastases Aims: The anaplastic lymphoma kinase gene (ALK) has attracted considerable attention as a potential molecular target in non-small-cell lung cancer (NSCLC). However, it is unclear whether ALK alterations are acquired during the metastatic progression of NSCLC. Methods and results: ALK status and ALK expression were evaluated in a series of 67 primary NSCLCs and their corresponding metastatic lesions using fluorescence in-situ hybridization and immunohistochemistry. ALK rearrangement was detected in 7.5% (5/67) of the primary tumours and in 9.0% (6/67) of the metastases (P < 0.001). ALK copy number gain (CNG) was detected in 1.5% (1/67) of the primary tumours and in 35.8% (24/67) of the metastases. Whereas ALK rearrangement was detected only in adenocarcinomas, CNG was identified in various histological subtypes of NSCLC. ALK expression was detected in 11.9% (8/67) of the primary tumours and in 25.4% (17/67) of the metastatic lesions. Conclusions: ALK alteration and ALK expression can be acquired during metastatic progression in NSCLC, and ALK CNG is associated with ALK expression. | - |
dc.language | 영어 | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Discordance between anaplastic lymphoma kinase status in primary non-small-cell lung cancers and their corresponding metastases | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/j.1365-2559.2012.04356.x | - |
dc.citation.journaltitle | Histopathology | - |
dc.identifier.wosid | 000312534000011 | - |
dc.identifier.scopusid | 2-s2.0-84871135647 | - |
dc.citation.endpage | 314 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 305 | - |
dc.citation.volume | 62 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Paik, Jin Ho | - |
dc.contributor.affiliatedAuthor | Choe, Gheeyoung | - |
dc.contributor.affiliatedAuthor | Jheon, Sanghoon | - |
dc.contributor.affiliatedAuthor | Lee, Choon-Taek | - |
dc.contributor.affiliatedAuthor | Chung, Jin-Haeng | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | IN-SITU-HYBRIDIZATION | - |
dc.subject.keywordPlus | EML4-ALK FUSION GENE | - |
dc.subject.keywordPlus | CLINICAL-FEATURES | - |
dc.subject.keywordPlus | COPY NUMBER | - |
dc.subject.keywordPlus | EGFR | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | REARRANGEMENT | - |
dc.subject.keywordPlus | KRAS | - |
dc.subject.keywordAuthor | ALK | - |
dc.subject.keywordAuthor | metastases | - |
dc.subject.keywordAuthor | non-small-cell lung cancer | - |
dc.subject.keywordAuthor | primary | - |
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