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Orthopaedic Manifestations of Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome
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Web of Science
Cited 11 time in Scopus
- Authors
- Issue Date
- 2011-01
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Citation
- Journal of Pediatric Orthopaedics, Vol.31 No.1, pp.107-112
- Abstract
- Background: Arthrogryposis-Renal dysfunction-Cholestasis (ARC) syndrome (MIM#208085) is a rare multisystem disorder, which involves the kidney, liver, skin, and central nervous and musculoskeletal systems. It is inherited as an autosomal-recessive trait, associated with germ-line mutations in the VPS33B gene. In this study, the authors reviewed the orthopaedic manifestations of ARC syndrome. Materials: Ten patients diagnosed as having ARC syndrome were the subjects of this study. ARC syndrome was confirmed by mutation analysis in 8 of the 10 patients. Medical records and radiographs were retrospectively reviewed with a focus on musculoskeletal manifestations. Results: Seven patients either expired at 4 to 19 months of age or were presumed to have expired. The remaining 3 patients remained alive at the time of writing this manuscript and were aged from 7 to 23 months. All patients showed musculoskeletal symptoms and/or signs, which included vertical talus (7 feet, 4 patients), pes calcaneovalgus (4 feet, 3 patients), hip dislocation (6 hips, 3 patients), pathologic fractures (5 fractures in 5 patients), and rigid kyphosis (2 patients). No surgical intervention was performed. Orthopaedic treatments, other than fracture management, were abandoned soon after diagnoses were made. Conclusions: ARC syndrome should be included in the differential diagnosis of arthrogryposis. As there is no specific effective treatment for renal dysfunction and cholestasis, orthopaedic intervention should be postponed until long-term survival is expected, though this is unlikely.
- ISSN
- 0271-6798
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