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GITR Agonism Triggers Antitumor Immune Responses through IL21-Expressing Follicular Helper T Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koh, Choong-Hyun | - |
dc.contributor.author | Kim, Il-Kyu | - |
dc.contributor.author | Shin, Kwang-Soo | - |
dc.contributor.author | Jeon, Insu | - |
dc.contributor.author | Song, Boyeong | - |
dc.contributor.author | Lee, Jeong-Mi | - |
dc.contributor.author | Bae, Eun-Ah | - |
dc.contributor.author | Seo, Hyungseok | - |
dc.contributor.author | Kang, Tae-Seung | - |
dc.contributor.author | Kim, Byung-Seok | - |
dc.contributor.author | Chung, Yeonseok | - |
dc.contributor.author | Kang, Chang-Yuil | - |
dc.date.accessioned | 2023-05-08T08:25:14Z | - |
dc.date.available | 2023-05-08T08:25:14Z | - |
dc.date.created | 2020-06-02 | - |
dc.date.created | 2020-06-02 | - |
dc.date.created | 2020-06-02 | - |
dc.date.created | 2020-06-02 | - |
dc.date.created | 2020-06-02 | - |
dc.date.created | 2020-06-02 | - |
dc.date.created | 2020-06-02 | - |
dc.date.issued | 2020-05 | - |
dc.identifier.citation | Cancer immunology research, Vol.8 No.5, pp.698-709 | - |
dc.identifier.issn | 2326-6066 | - |
dc.identifier.uri | https://hdl.handle.net/10371/192149 | - |
dc.description.abstract | Although treatment with the glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) agonistic antibody (DTA-1) has shown antitumor activity in various tumor models, the underlying mechanism is not fully understood. Here, we demonstrate that interleukin (IL)-21-producing follicular helper T (Tfh) cells play a crucial role in DTA-1-induced tumor inhibition. The administration of DTA-1 increased IL21 expression by Tfh cells in an antigen-specific manner, and this activation led to enhanced antitumor cytotoxic T lymphocyte (CTL) activity. Mice treated with an antibody that neutralizes the IL21 receptor exhibited decreased antitumor activity when treated with DTA-1. Tumor growth inhibition by DTA-1 was abrogated in Bcl6(fl/fl)Cd4(Cre) mice, which are genetically deficient in Tfh cells. IL4 was required for optimal induction of IL21-expressing Tfh cells by GITR costimulation, and c-Maf mediated this pathway. Thus, our findings identify GITR costimulation as an inducer of IL21-expressing Tfh cells and provide a mechanism for the antitumor activity of GITR agonism. | - |
dc.language | 영어 | - |
dc.publisher | American Association for Cancer Research Inc. | - |
dc.title | GITR Agonism Triggers Antitumor Immune Responses through IL21-Expressing Follicular Helper T Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1158/2326-6066.CIR-19-0748 | - |
dc.citation.journaltitle | Cancer immunology research | - |
dc.identifier.wosid | 000531795400011 | - |
dc.identifier.scopusid | 2-s2.0-85084961204 | - |
dc.citation.endpage | 709 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 698 | - |
dc.citation.volume | 8 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Seo, Hyungseok | - |
dc.contributor.affiliatedAuthor | Chung, Yeonseok | - |
dc.contributor.affiliatedAuthor | Kang, Chang-Yuil | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TUMOR-IMMUNITY | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | IL-21 | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ANTIBODY | - |
dc.subject.keywordPlus | BCL6 | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | INCREASES | - |
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