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Differentiation of c-Kit(+)CD24(+) natural killer cells into myeloid cells in a GATA-2-dependent manner
DC Field | Value | Language |
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dc.contributor.author | Song, Boyeong | - |
dc.contributor.author | Lee, Jeong-Mi | - |
dc.contributor.author | Park, Young-Jun | - |
dc.contributor.author | Kim, Il-Kyu | - |
dc.contributor.author | Kim, Byung-Seok | - |
dc.contributor.author | Shin, Kwang-Soo | - |
dc.contributor.author | Jeon, Insu | - |
dc.contributor.author | Koh, Choong-Hyun | - |
dc.contributor.author | Bae, Eun-Ah | - |
dc.contributor.author | Seo, Hyungseok | - |
dc.contributor.author | Byun, Youngro | - |
dc.contributor.author | Kang, Chang-Yuil | - |
dc.date.accessioned | 2023-05-08T08:25:17Z | - |
dc.date.available | 2023-05-08T08:25:17Z | - |
dc.date.created | 2020-10-14 | - |
dc.date.created | 2020-10-14 | - |
dc.date.created | 2020-10-14 | - |
dc.date.created | 2020-10-14 | - |
dc.date.created | 2020-10-14 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.citation | FASEB Journal, Vol.34 No.3, pp.4462-4481 | - |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.uri | https://hdl.handle.net/10371/192150 | - |
dc.description.abstract | Myeloid progenitor cells have generally been considered the predominant source of myeloid cells under steady-state conditions. Here we show that NK cells contributed to a myeloid cell lineage pool in naive and tumor-bearing mice. Using fate tracing of NKp46(+) cells, we found that myeloid cells could be derived from NK cells. Notably, among mature CD11b(+)CD27(+) NK cells, c-Kit(+)CD24(+) NK cells were capable of differentiating into a range of myeloid lineages in vitro and produced neutrophils and monocytes in vivo. The differentiation was completely inhibited by NK-stimulating cytokines. In addition to the potential for differentiation into myeloid cells, c-Kit(+)CD24(+) NK cells retained NK cell phenotypes and effector functions. Mechanistically, GATA-2 was necessary for the differentiation of c-Kit(+)CD24(+) NK cells. Therefore, we discovered that GATA-2-dependent differentiation of c-Kit(+)CD24(+) NK cells contributes to myeloid cell development and identified a novel pathway for myeloid lineage commitment under physiological conditions. | - |
dc.language | 영어 | - |
dc.publisher | Federation of American Societies for Experimental Biology | - |
dc.title | Differentiation of c-Kit(+)CD24(+) natural killer cells into myeloid cells in a GATA-2-dependent manner | - |
dc.type | Article | - |
dc.identifier.doi | 10.1096/fj.201902662R | - |
dc.citation.journaltitle | FASEB Journal | - |
dc.identifier.wosid | 000509780000001 | - |
dc.identifier.scopusid | 2-s2.0-85078763593 | - |
dc.citation.endpage | 4481 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 4462 | - |
dc.citation.volume | 34 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Seo, Hyungseok | - |
dc.contributor.affiliatedAuthor | Byun, Youngro | - |
dc.contributor.affiliatedAuthor | Kang, Chang-Yuil | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PRECURSOR ACUTE-LEUKEMIA | - |
dc.subject.keywordPlus | NK-CELLS | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | B-CELLS | - |
dc.subject.keywordPlus | LINEAGE | - |
dc.subject.keywordPlus | PROGENITOR | - |
dc.subject.keywordPlus | CONVERSION | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordAuthor | CD24 | - |
dc.subject.keywordAuthor | c-Kit | - |
dc.subject.keywordAuthor | GATA-2 | - |
dc.subject.keywordAuthor | myeloid cell development | - |
dc.subject.keywordAuthor | natural killer cell | - |
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