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Monocyte-derived dendritic cells dictate the memory differentiation of CD8+ T cells during acute infection
DC Field | Value | Language |
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dc.contributor.author | Shin, Kwang-Soo | - |
dc.contributor.author | Jeon, Insu | - |
dc.contributor.author | Kim, Byung-Seok | - |
dc.contributor.author | Kim, Il-Kyu | - |
dc.contributor.author | Park, Young-Jun | - |
dc.contributor.author | Koh, Choong-Hyun | - |
dc.contributor.author | Song, Boyeong | - |
dc.contributor.author | Lee, Jeong-Mi | - |
dc.contributor.author | Lim, Jiyoung | - |
dc.contributor.author | Bae, Eun-Ah | - |
dc.contributor.author | Seo, Hyungseok | - |
dc.contributor.author | Ban, Young Ho | - |
dc.contributor.author | Ha, Sang-Jun | - |
dc.contributor.author | Kang, Chang-Yuil | - |
dc.date.accessioned | 2023-05-08T08:25:25Z | - |
dc.date.available | 2023-05-08T08:25:25Z | - |
dc.date.created | 2020-04-10 | - |
dc.date.created | 2020-04-10 | - |
dc.date.created | 2020-04-10 | - |
dc.date.created | 2020-04-10 | - |
dc.date.created | 2020-04-10 | - |
dc.date.issued | 2019-08 | - |
dc.identifier.citation | Frontiers in Immunology, Vol.10 No.AUG | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | https://hdl.handle.net/10371/192152 | - |
dc.description.abstract | Monocyte-derived dendritic cells (moDCs) have been shown to robustly expand during infection; however; their roles in anti-infectious immunity remain unclear. Here, we found that moDCs were dramatically increased in the secondary lymphoid organs during acute LCMV infection in an interferon-gamma (IFN-gamma)-dependent manner. We also found that priming by moDCs enhanced the differentiation of memory CD8(+) T cells compared to differentiation primed by conventional dendritic cells (cDCs) through upregulation of Eomesodermin (Eomes) and T cell factor-1 (TCF-1) expression in CD8(+) T cells. Consequently, impaired memory formation of CD8(+) T cells in mice that had reduced numbers of moDCs led to defective clearance of pathogens upon rechallenge. Mechanistically, attenuated interleukin-2 (IL-2) signaling in CD8(+) T cells primed by moDCs was responsible for the enhanced memory programming of CD8(+) T cells. Therefore, our findings unveil a specialization of the antigen-presenting cell subsets in the fate determination of CD8(+) T cells during infection and pave the way for the development of a novel therapeutic intervention on infection. | - |
dc.language | 영어 | - |
dc.publisher | Frontiers Media S.A. | - |
dc.title | Monocyte-derived dendritic cells dictate the memory differentiation of CD8+ T cells during acute infection | - |
dc.type | Article | - |
dc.identifier.doi | 10.3389/fimmu.2019.01887 | - |
dc.citation.journaltitle | Frontiers in Immunology | - |
dc.identifier.wosid | 000481443200001 | - |
dc.identifier.scopusid | 2-s2.0-85071766508 | - |
dc.citation.number | AUG | - |
dc.citation.volume | 10 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Seo, Hyungseok | - |
dc.contributor.affiliatedAuthor | Kang, Chang-Yuil | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | IL-2 PRODUCTION | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | EFFECTOR | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | INTERFERON | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SUBSETS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordAuthor | monocyte-derived dendritic cells | - |
dc.subject.keywordAuthor | memory CD8(+) T cells | - |
dc.subject.keywordAuthor | IFN-gamma | - |
dc.subject.keywordAuthor | LCMV | - |
dc.subject.keywordAuthor | acute infection | - |
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