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Roles of NKT cells in cancer immunotherapy

Cited 59 time in Web of Science Cited 67 time in Scopus
Authors

Bae, Eun-Ah; Seo, Hyungseok; Kim, Il-Kyu; Jeon, Insu; Kang, Chang-Yuil

Issue Date
2019-07
Publisher
대한약학회
Citation
Archives of Pharmacal Research, Vol.42 No.7, pp.543-548
Abstract
Cancer immunotherapy has emerged as an effective therapeutic strategy to treat cancer. Among diverse immune populations, invariant natural killer T (iNKT) cells have shown potent antitumor activity by linking innate and adaptive immune systems. Upon activation by lipid antigens on CD1d molecules, iNKT cells rapidly produce various cytokines and trigger antitumor immunity directly or indirectly by activating other antitumor immune cells. Administration of a representative iNKT cell ligand alpha-galactosylceramide (-GalCer) or -GalCer-pulsed APCs effectively stimulates iNKT cells and thereby induces antitumor effects. In this review, we will introduce the biology and importance of NKT cells in antitumor immunity. Previous studies have demonstrated that iNKT cells not only activate various immune cells but also reinvigorate exhausted immune cells in the tumor microenvironment. Furthermore, we will summarize the major clinical trials utilizing iNKT-based immunotherapies.
ISSN
0253-6269
URI
https://hdl.handle.net/10371/192153
DOI
https://doi.org/10.1007/s12272-019-01139-8
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