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GM-CSF promotes antitumor immunity by inducing Th9 cell responses
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Il-Kyu | - |
dc.contributor.author | Koh, Choong-Hyun | - |
dc.contributor.author | Jeon, Insu | - |
dc.contributor.author | Shin, Kwang-Soo | - |
dc.contributor.author | Kang, Tae-Seung | - |
dc.contributor.author | Bae, Eun-Ah | - |
dc.contributor.author | Seo, Hyungseok | - |
dc.contributor.author | Ko, Hyun-Ja | - |
dc.contributor.author | Kim, Byung-Seok | - |
dc.contributor.author | Chung, Yeonseok | - |
dc.contributor.author | Kang, Chang-Yuil | - |
dc.date.accessioned | 2023-05-08T08:25:35Z | - |
dc.date.available | 2023-05-08T08:25:35Z | - |
dc.date.created | 2019-10-23 | - |
dc.date.created | 2019-10-23 | - |
dc.date.created | 2019-10-23 | - |
dc.date.created | 2019-10-23 | - |
dc.date.created | 2019-10-23 | - |
dc.date.created | 2019-10-23 | - |
dc.date.issued | 2019-03 | - |
dc.identifier.citation | Cancer Immunology Research, Vol.7 No.3, pp.498-509 | - |
dc.identifier.issn | 2326-6066 | - |
dc.identifier.uri | https://hdl.handle.net/10371/192154 | - |
dc.description.abstract | GM-CSF as an adjuvant has been shown to promote anti-tumor immunity in mice andhumans; however, theunderlying mechanism ofGM-CSF-induced antitumorimmunity remains incompletely understood. In this study, we demonstrate that GM-CSF potentiates the efficacy of cancer vaccines through IL9-producing Th (Th9) cells. GM-CSF selectively enhanced Th9 cell differentiation by regulating theCOX2-PGE2 pathway while inhibiting the differentiation of induced regulatory T (iTreg) cells in vitro and in vivo. GM-CSF-activated monocyte-derived dendritic cells converted tumor-specific naive Th cells into Th9 cells, and delayed tumor growth by inducing antitumor CTLs in an IL9-dependent manner. Our findings reveal a mechanism for the adjuvanticity of GM-CSF and provide a rationale for the use of GM-CSF in cancer vaccines. | - |
dc.language | 영어 | - |
dc.publisher | American Association for Cancer Research Inc. | - |
dc.title | GM-CSF promotes antitumor immunity by inducing Th9 cell responses | - |
dc.type | Article | - |
dc.identifier.doi | 10.1158/2326-6066.CIR-18-0518 | - |
dc.citation.journaltitle | Cancer Immunology Research | - |
dc.identifier.wosid | 000460097000014 | - |
dc.identifier.scopusid | 2-s2.0-85062269619 | - |
dc.citation.endpage | 509 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 498 | - |
dc.citation.volume | 7 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Seo, Hyungseok | - |
dc.contributor.affiliatedAuthor | Chung, Yeonseok | - |
dc.contributor.affiliatedAuthor | Kang, Chang-Yuil | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CD4(+) T-CELLS | - |
dc.subject.keywordPlus | COLONY-STIMULATING FACTORS | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | METASTATIC MELANOMA | - |
dc.subject.keywordPlus | TUMOR-IMMUNITY | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | SYNERGIZES | - |
dc.subject.keywordPlus | INDUCTION | - |
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