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Class III β-Tubulin Shows Unique Expression Patterns in a Variety of Neoplastic and Non-neoplastic Lymphoproliferative Disorders : Class III beta-Tubulin Shows Unique Expression Patterns in a Variety of Neoplastic and Non-neoplastic Lymphoproliferative Disorders
DC Field | Value | Language |
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dc.contributor.author | Yoon, Sun Och | - |
dc.contributor.author | Kim, Wook Youn | - |
dc.contributor.author | Go, Heounjeong | - |
dc.contributor.author | Paik, Jin Ho | - |
dc.contributor.author | Kim, Ji Eun | - |
dc.contributor.author | Kim, Young A. | - |
dc.contributor.author | Huh, Joo R. | - |
dc.contributor.author | Jeon, Yoon Kyung | - |
dc.contributor.author | Kim, Chul-Woo | - |
dc.date.accessioned | 2023-05-08T08:26:00Z | - |
dc.date.available | 2023-05-08T08:26:00Z | - |
dc.date.created | 2022-04-08 | - |
dc.date.created | 2022-04-08 | - |
dc.date.issued | 2010-05 | - |
dc.identifier.citation | American Journal of Surgical Pathology, Vol.34 No.5, pp.645-655 | - |
dc.identifier.issn | 0147-5185 | - |
dc.identifier.uri | https://hdl.handle.net/10371/192162 | - |
dc.description.abstract | Class III beta-tubulin (TUBB3) expression in carcinoma is associated with resistance to tubulin-binding chemotherapeutic agents. Recently, follicular dendritic cells (FDCs) were reported to express TUBB3 under physiologic conditions. We investigated TUBB3 expression in a wide range of lymphoproliferative disorders using immunohistochemistry. Dual immuno-staining for Bcl-6 and TUBB3 revealed that some germinal center B cells also express TUBB3 in addition to FDCs. In Hodgkin lymphomas (HLs), 47.1% (40/85) expressed TUBB3 in the tumor cells with an all-or-none pattern. TUBB3 expression in HL was more common in mixed cellularity type than nodular sclerosis type (P = 0.032). Among non-HLs, 79.3% (23/29) of anaplastic large cell lymphoma (ALCL), 8% (2/25) of extra-nodal natural killer/T-cell lymphoma, and 75% (21/28) of Burkitt lymphoma showed TUBB3 expression with an all-or-none pattern. Of diffuse large B-cell lymphoma, 15.2% (32/210) expressed TUBB3 in a heterogeneous pattern. In ALCL, TUBB3 expression was more common in systemic ALCL than in primary cutaneous ALCL (P = 0.046). Diffuse large B-cell lymphomas with a germinal center B-like subgroup exhibited TUBB3 expression more frequently than non-GCB-like subgroup (P = 0.01). Otherwise, none of the 18 angioimmunoblastic T-cell lymphomas; 18 peripheral T-cell lymphomas, not otherwise specified; 12 follicular lymphomas; 62 marginal zone lymphomas; 7 mantle cell lymphomas; 8 small lymphocytic lymphomas; or 2 FDC sarcomas expressed TUBB3. In angioimmunoblastic T-cell lymphoma and Castleman disease, TUBB3 was positive in immunoblasts corresponding to Epstein-Barr virus-infected or Kaposi sarcoma herpes virus-infected cells. A variety of neoplastic and non-neoplastic lymphoproliferative disorders exhibited characteristic TUBB3 expression patterns; these results suggest potential for diagnostic utility, some insight into the pathobiology of TUBB3 expression, and potential therapeutic implications. | - |
dc.language | 영어 | - |
dc.publisher | Lippincott Williams & Wilkins Ltd. | - |
dc.title | Class III β-Tubulin Shows Unique Expression Patterns in a Variety of Neoplastic and Non-neoplastic Lymphoproliferative Disorders | - |
dc.title.alternative | Class III beta-Tubulin Shows Unique Expression Patterns in a Variety of Neoplastic and Non-neoplastic Lymphoproliferative Disorders | - |
dc.type | Article | - |
dc.identifier.doi | 10.1097/PAS.0b013e3181d5d903 | - |
dc.citation.journaltitle | American Journal of Surgical Pathology | - |
dc.identifier.wosid | 000277614800006 | - |
dc.identifier.scopusid | 2-s2.0-77951800247 | - |
dc.citation.endpage | 655 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 645 | - |
dc.citation.volume | 34 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Paik, Jin Ho | - |
dc.contributor.affiliatedAuthor | Kim, Ji Eun | - |
dc.contributor.affiliatedAuthor | Kim, Chul-Woo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | B-CELL-LYMPHOMA | - |
dc.subject.keywordPlus | MICROTUBULE ALTERATIONS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordPlus | MARKER | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordAuthor | class III beta-tubulin | - |
dc.subject.keywordAuthor | Hodgkin lymphoma | - |
dc.subject.keywordAuthor | non-Hodgkin lymphoma | - |
dc.subject.keywordAuthor | lymphoproliferative disorder | - |
dc.subject.keywordAuthor | follicular dendritic cell | - |
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