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Comparison of Lymph Node Metastases Assessment with the Use of USPIO-Enhanced MR Imaging at 1.5 T Versus 3.0 T in a Rabbit Model
DC Field | Value | Language |
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dc.contributor.author | Choi, Seung Hong | - |
dc.contributor.author | Kim, Keon Ha | - |
dc.contributor.author | Moon, Woo Kyung | - |
dc.contributor.author | Kim, Hyo-Cheol | - |
dc.contributor.author | Cha, Joo Hee | - |
dc.contributor.author | Paik, Jin Ho | - |
dc.contributor.author | Chang, Kee-Hyun | - |
dc.date.accessioned | 2023-05-08T08:26:18Z | - |
dc.date.available | 2023-05-08T08:26:18Z | - |
dc.date.created | 2021-04-09 | - |
dc.date.created | 2021-04-09 | - |
dc.date.issued | 2010-01 | - |
dc.identifier.citation | Journal of Magnetic Resonance Imaging, Vol.31 No.1, pp.134-141 | - |
dc.identifier.issn | 1053-1807 | - |
dc.identifier.uri | https://hdl.handle.net/10371/192168 | - |
dc.description.abstract | Purpose: To prospectively compare the diagnostic performances of 1.5 T and 3.0 T ultrasmall superparamagnetic iron oxide (USPIO)-enhanced magnetic resonance imaging (MRI) for the detection of lymph node (LN) metastases in a rabbit model. Materials and Methods: Experiments were approved by the animal care committee. VX2 carcinomas were implanted into the thighs of 18 rabbits 3 or 4 weeks before MRI examinations. T2*-weighted 1.5 T and 3.0 T MRI was performed 24 hours after USPIO (2.6 mg/kg iron) administration. Two radiologists calculated signal intensity (SI) ratios (ie, the ratios of postcontrast to precontrast signal intensity) of each LN and also evaluated for the presence of a metastasis in the iliac and retroperitoneal LNs at 1.5 T and 3.0 T MRI. Student's t-test, receiver operating characteristic (ROC) curve analysis, and a Z test were used for the statistical analysis. Results: Metastases were confirmed in 45 of 80 LNs by histopathology. For benign LNs the mean SI ratio at 1.5 T was higher (0.538) than at 3.0 T (0.463) (P = 0.004). In qualitative analysis, 1.5 T and 3.0 T USPIO-enhanced MRI showed similar Az values (0.951 vs. 0.939; P = 0.296). The specificity of 3.0 T USPIO-enhanced MRI was higher (91.4% [32 of 35]) than that of 1.5 T imaging (82.9% [29 of 35]) (P = 0.013); however, the sensitivities (88.9% [40 of 45]) were the same in the both modalities. Conclusion: 3.0 T USPIO-enhanced MRI shows a higher specificity as compared to 1.5 T imaging without a significant difference of sensitivity in a rabbit VX2 model. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Comparison of Lymph Node Metastases Assessment with the Use of USPIO-Enhanced MR Imaging at 1.5 T Versus 3.0 T in a Rabbit Model | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/jmri.22020 | - |
dc.citation.journaltitle | Journal of Magnetic Resonance Imaging | - |
dc.identifier.wosid | 000273336100017 | - |
dc.identifier.scopusid | 2-s2.0-74049133910 | - |
dc.citation.endpage | 141 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 134 | - |
dc.citation.volume | 31 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Choi, Seung Hong | - |
dc.contributor.affiliatedAuthor | Moon, Woo Kyung | - |
dc.contributor.affiliatedAuthor | Paik, Jin Ho | - |
dc.contributor.affiliatedAuthor | Chang, Kee-Hyun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SUPERPARAMAGNETIC IRON-OXIDE | - |
dc.subject.keywordPlus | PROSTATE-CANCER | - |
dc.subject.keywordPlus | CONTRAST | - |
dc.subject.keywordAuthor | experimental study | - |
dc.subject.keywordAuthor | iron | - |
dc.subject.keywordAuthor | lymphatic system | - |
dc.subject.keywordAuthor | magnetic resonance (MR) | - |
dc.subject.keywordAuthor | contrast media | - |
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